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    Industrial pharmaceutical sterilization equipment including an autoclave tunnel, sterilization chamber with digital control panel, and modular processing units — designed for sterile fill-finish and regulatory-compliant drug manufacturing.

    Pharmaceutical sterilization of products and parts

    Efficiently sterilize liquid pharmaceuticals in open or closed containers and equipment to ensure regulatory compliance, availability and reliability.

    Connect with our experts Sterilization downloads

    The highest safety and reliability for your pharmaceutical sterilization requirements

    Liquid drug manufacturing requires reliable, regulatory compliant pharmaceutical sterilization, backed by short qualification times and a stable ramp-up. With our global expert network, easy to use machines and tailored training, you reduce risk in daily operations and gain the peace of mind that your sterilization process will simply work.

    Far more than autoclaves: your lifecycle partner for efficient pharmaceutical sterilization

    How to ensure regulatory Annex 1 compliance?

    Regulatory compliance is built into our sterilization systems by default.

    How to achieve the highest equipment availability?

    Trust in our sterilizers with high uptime, fast ramp-up and global service.

    How to secure long-term efficiency in sterilization?

    Achieve full control with optimized energy use and predictable lifecycle cost.

    Explore our pharmaceutical sterilization solutions

    Overall 6 Solutions
    Process
    Application
    Layout
    Feature 1
    Feature 2
    Feature 3
    Feature 4
    Benefits
    Syntegon Aquatherm hot‑water shower sterilizer with overhead tank and piping; for sealed liquid containers (ampoules, vials); uniform heat via guided water distribution.
    Aquatherm
    Process
    Hot water shower
    Application
    Liquid pharmaceuticals
    Layout
    Highly customizable
    Feature 1
    Unique water distribution design
    Feature 2
    High-quality FDA-compliant heat exchangers
    Feature 3
    Maintenance-friendly water showering system
    Feature 4
    Cylindrical chamber for long service life
    Benefits

    Best if you want:

    • Significantly reduced process times at low volume flow
    • Optimized energy and process water needs
    • Automated loading and unloading
    Brochure
    Syntegon Rototherm steam/air‑mixture sterilizer with automated tray loading; for liquid pharmaceuticals in open containers; baffle plates ensure even, fast heating.
    Rototherm
    Process
    Steam/air mixture
    Application
    Liquid pharmaceuticals
    Layout
    Highly customizable
    Feature 1
    High circulation performance
    Feature 2
    Dedicated flow guidance
    Feature 3
    Highly efficient cooling
    Feature 4
    Robotics for loading and unloading
    Benefits

    Best if you want:

    • Optimum flow guidance for uniform temperature distribution
    • Dry product at cycle end
    • Low long-term temperatures for pasteurization
    Brochure
    Syntegon Vakutherm vacuum‑steam sterilizer with front‑loading chamber and HMI; ideal for porous loads (instruments, packaged goods); robust chamber and jacket for long life.
    Vakutherm
    Process
    Vacuum-steam, vacuum-steam/air combination
    Application
    Porous loads & liquid pharmaceuticals
    Layout
    Highly customizable
    Feature 1
    Highest reliable sterilization performance
    Feature 2
    Optimized chamber and jacket design
    Feature 3
    Extension with steam/air mixture possible
    Feature 4
    Intelligent maintenance management
    Benefits

    Best if you want:

    • Tailor made solutions for highest demands
    • Usable from lab to production
    • High-quality standard components for fast availability
    Brochure
    Syntegon RackSter vacuum-steam parts sterilizer on a mobile multi-rack platform; designed for aseptic line batch changeovers and automated steam sterilization of pharmaceutical equipment parts.
    RackSter
    Process
    Vacuum-steam
    Application
    Parts sterilization and aseptic line batch changeovers
    Layout
    Modular with configuration options
    Feature 1
    Max safety, minimum contamination risk
    Feature 2
    Significantly faster batch changeovers
    Feature 3
    Mobile sterilization & transfer system
    Feature 4
    Fully automatic parts transfer
    Benefits

    Best if you want:

    • Shorter batch changeover and docking times
    • Increased filling line availability and throughput
    • Full Annex 1 compliance from day one
    Syntegon SteriSigma modular pharmaceutical sterilizer supporting vacuum-steam and steam/air combination processes; for liquid pharmaceuticals and porous loads including ampoules, vials, and blister-packed goods.
    SteriSigma
    Process
    Vacuum-steam, steam/air and combination
    Application
    Liquid pharmaceuticals & porous loads
    Layout
    Modular with configuration options
    Feature 1
    Precise temperature and pressure control
    Feature 2
    Pressure vessel available in 6 sizes
    Feature 3
    Chamber volumes from 400-3,000 liters
    Feature 4
    Configurable, user-friendly software
    Benefits

    Best if you want:

    • Unique quality-price ratio
    • Short delivery times
    • Modular platform with high reliability and high-performance control system
    Brochure
    Syntegon SteriEtox ethylene oxide sterilization system for medical devices; fully automated to minimize EO exposure during sterilization of catheters, stents, and complex assembled devices.
    SteriEtox
    Process
    Ethylene oxide
    Application
    Medical devices
    Layout
    Highly customizable
    Feature 1
    Automated for operator safety & low OPEX
    Feature 2
    Integrated emission reduction
    Feature 3
    Continuous inline sterilization tunnel
    Feature 4
    Seamless automated material flow
    Benefits

    Best if you want:

    • Maximum operator safety & reduced operating costs
    • End-to-end streamlined process
    • Reduced emissions and real-time monitoring systems
    Featured_Download_Teaser_Sterilizer_Portfolio_Brochure

    Flexible solutions for terminal sterilization and parts sterilization

    This overview highlights key applications, benefits and features of Syntegon’s sterilizers.

    • Match the right process to liquids, medical devices and porous goods
    • Use systems in production, laboratory and R&D settings
    • Reduce energy and media consumption with optimized designs
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    Pharmaceutical sterilization simplifies compliance and ensures availability

    Syntegon pharmaceutical autoclave sterilizers on a manufacturing floor, showcasing over 50 years of sterilization expertise and more than 2,000 installed units across 50+ countries.

    More than 2,000 installed units

    Proof of market-leading pharmaceutical sterilization quality in over 50 countries.
    Syntegon Aquatherm hot‑water shower sterilizer with overhead tank and operator beside stacked trays, illustrating up to 20% energy savings from its design.

    Up to 20 % energy savings

    Achieved with the special design features of our hot water shower sterilizers.
    Close-up of a hand holding a contact lens, representing the high share of disposable contacts sterilized using Syntegon pharmaceutical equipment.

    More than 60 % of all disposable contact lenses

    Sterilized with Syntegon pharmaceutical sterilization equipment.
    Close-up of a person inserting a disposable contact lens, illustrating Syntegon's case study on sterilizing over 60% of the world's contact lenses with 99.9% equipment availability.
    Case Study

    Up to 99.9 percent availability with Syntegon sterilizer

    More than 60 percent of all disposable contact lenses worldwide are sterilized on Syntegon equipment and deliver exceptional availability and ensure 24/7 operations, where needed.

    value-icon-innovative-technologies
    Innovative Technologies We enable market leadership.
    Close-up of the Syntegon RackSter stainless steel vacuum-steam sterilizer docking interface, showing the sealed transfer port and isolator connection mechanism for contamination-free sterile parts transfer.
    HIGHLIGHT TOPIC

    RackSter – revolutionizing sterile isolator parts transfer

    Our mobile steam-sterilizable multirack containment system ensures shorter changeovers and docking times, minimizes contamination risk and maximizes filling line output.

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    Your strategic lifecycle partner for pharmaceutical sterilization

    service-life-cycle
    Ready for everything, from start to routine

    From installation to optimization, Syntegon supports you with structured service packages, training, and specialists – for safe, stable and resilient production across the lifecycle.

    service-life-uptime
    Secure availability – every day

    Fast spare parts, qualified support and preventive maintenance help you avoid unplanned downtime, protect performance and keep daily operations reliable.

    service-future-ready
    Make your line fit for tomorrow

    Scalable retrofits, data solutions and handling/automation systems help you adapt to new demands, improve OEE and keep your lines future-proof across changing requirements.

    Pharmaceutical sterilization knowledge hub

    Flexible solutions for terminal sterilization and parts sterilization
    Flexible solutions for terminal sterilization and parts sterilization

    Overview of sterilizers for pharmaceutical applications: reliable, efficient, compliance, safety and consistent quality.

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    Hot water shower sterilizer for sealed containers
    Hot water shower sterilizer for sealed containers

    Understand rapid heating and cooling, support pressure control and water distribution that protect sealed containers. Review options for energy recovery and monitoring.

    Download
    Vacuum steam sterilizers for equipment and components
    Vacuum steam sterilizers for equipment and components

    Understand vacuum steam cycles with evacuating, heating, sterilizing, drying and venting steps for equipment and porous loads.

    Download
    Steam air mixture sterilizer for liquid products
    Steam air mixture sterilizer for liquid products

    See how steam air mixture cycles, support pressure and radial fans protect containers and ensure uniform temperature.

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    Modular steam sterilizers for pharma and biotech lines
    Modular steam sterilizers for pharma and biotech lines

    See chamber sizes, process variants and options to configure SteriSigma units for production, lab and R&D sterilization tasks.

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    Interested in pharmaceutical sterilization?

    Interested in pharmaceutical sterilization?

    Talk to a Syntegon expert to learn more about sterilization solutions.

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    News

    WFI membrane process: soon a global standard?
    WFI membrane process: soon a global standard?

    Discover the energy-efficient membrane processes for producing water for injection (WFI). Learn how they work and key considerations for optimal results.

    Learn more
    RackSter: revolutionizing aseptic batch changeovers
    RackSter: revolutionizing aseptic batch changeovers

    Discover RackSter, steam-sterilizable mobile multirack system for automated, gloveless sterile parts transfer and faster aseptic batch changeovers.

    Learn more
    Pharmaceutical cleaning solutions and depyrogenation tunnels
    Pharmaceutical cleaning solutions and depyrogenation tunnels

    Explore pharmaceutical cleaning solutions and depyrogenation tunnels designed for reliable sterilization, high output, validation, flexibility, and energy-efficient production.

    Learn more