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    Droplet of purified water falling into glass dish symbolizing pharmaceutical pure media generation for PW and WFI utilities

    Pure Media for efficient pharma utilities

    Reduce energy costs and qualification effort of your Pure Media systems while securing hygienic, reliable generation of PW, WFI, and Pure Steam.

    Connect with our experts Pure Media downloads

    Secure pure media reliability and sustainability

    Rising energy costs, limited floor space, and growing qualification demands put constant pressure on your Pure Media operations.

    As your strategic partner, Syntegon addresses all three – with modular membrane and thermal systems, integrated storage and distribution, and full lifecycle support that keeps your pure media utilities running smoothly.

    Pure Media systems you can count on

    How to reduce energy usage in Pure Media generation?

    Ask our experts about our energy-efficiency upgrades and Pure Media systems.

    How to ensure safe and reliable Pure Media processes?

    Trust in Pure Media solutions from Syntegon and more than 30 years of expertise.

    How to achieve maximum flexibility in Pure Media generation?

    Rely on our modular and customizable Pure Media systems and lifecycle services.

    Explore our pure media solutions

    Overall 6 Solutions
    Application
    Technology
    Product quality
    Cleaning features
    Capacity control
    Monitoring options
    Benefits
    Syntegon PTS raw water pretreatment skid with filters dosing tanks and pumps for pharmaceutical purified water generation
    PTS
    Application
    Raw Water Pretreatment
    Technology
    Filtration, adsorption, chemical dosing, temperature control
    Product quality
    Drinking water acc. to local regulations
    Cleaning features
    Hot water or chemical sanitization
    Capacity control
    0…100% (standard)
    Monitoring options
    Conductivity
    Benefits

    Best if you want:

    • Configure modular, flexible setups 
    • Tailor solutions to on-site conditions 
    • Cover a broad technology range 
    • Achieve precise product conditioning 
    Contact our experts
    Syntegon PWGU skid for membrane based purified water generation with stainless steel piping and control cabinet
    PWGU
    Application
    Purified Water generation
    Technology
    Softening, RO, membrane degassing, EDI
    Product quality
    Purified Water acc. to USP, Ph. Eur. and JP
    Cleaning features
    Hot water or chemical sanitization
    Capacity control
    0…100% (standard)
    Monitoring options
    TOC, Bacterial count
    Benefits

    Best if you want:

    • Compact design
    • Easy maintenance
    • Sustainable WFI production
    Read success story
    Syntegon MWFI skid for cold membrane based WFI generation using RO, EDI and UF with compact stainless steel frame and control cabinet
    MWFI / UF-Skid
    Application
    Membrane-based WFI generation
    Technology
    Softening, RO, membrane degassing, EDI, UF
    Product quality
    Water for Injection acc. to USP, Ph. Eur. and JP
    Cleaning features
    Hot water or chemical sanitization
    Capacity control
    0…100% (standard)
    Monitoring options
    TOC, Bacterial count, UF integrity during production
    Benefits

    Best if you want:

    • Compact design
    • Easy maintenance
    • Sustainable WFI production
    Download brochure
    Syntegon STILL multi column distillation unit for thermal WFI and Pure Steam generation with vertical columns and operator panel
    STILL
    Application
    Distillation-based WFI generation
    Technology
    Multi-effect distillation with natural circulation principle
    Product quality
    Water for Injection acc. to USP, Ph. Eur. and JP
    Cleaning features
    Self-sterilization
    Capacity control
    70…100% (option)
    Monitoring options
    TOC, Bacterial count
    Benefits

    Best if you want:

    • Intrinsic product safety
    • Highly robust with low scaling tendency
    • Corrosion resistant, hygienic design
    • Consistent quality for sterilization 
    Contact our experts
    Syntegon PSG pure steam generator with vertical natural circulation column and control cabinet for pharmaceutical sterilization utilities
    PSG
    Application
    Pure Steam generation
    Technology
    Evaporation with natural circulation principle
    Product quality
    Pure Steam acc. to USP, Ph. Eur. and JP
    Cleaning features
    Self-sterilization
    Capacity control
    0…100% (standard)
    Monitoring options
    TOC, EN285 steam quality
    Benefits

    Best if you want:

    • Highly robust with low scaling tendency
    • Corrosion resistant, hygienic design
    • Consistent quality for sterilization
    Download flyer
    Syntegon LUV pharmaceutical pure water storage tank with skid mounted monitoring unit for PW and WFI buffer and distribution
    LUV (S&D)
    Application
    Storage and distribution
    Technology
    Steady flow, cold, ambient or hot storage and distribution
    Product quality
    Supports PW, WFI and Pure Steam
    Cleaning features
    CIP/SIP
    Capacity control
    0…100% (standard)
    Monitoring options
    Bacterial count
    Benefits

    Best if you want:

    • Easily scalable due to modular design

    Contact our experts
    Featured_Download_Teaser_Pure_Media-1

    Everything you need to plan your membrane-based WFI system

    Learn how membrane-based WFI generation reduces energy consumption while remaining fully compliant – and what it takes to design a safe and reliable process.

    • Understand the key regulatory requirements for WFI generation
    • Design safe and compliant membrane-based processes
    • Build a strong foundation with the right partner
    Download brochure

    Pure Media features that reduce costs, carbon emissions and simplify compliance

    Operator in cleanroom clothing operating Syntegon MWFI membrane WFI generator skid for energy efficient WFI production

    Up to 95% lower WFI OPEX with MWFI

    Cut utility spend and free up floor space – without compromising WFI stability or quality.
    Syntegon PSG pure steam generator skid with vertical column for pharmaceutical sterilization utilities

    Up to 7,500 kg Pure Steam per hour

    Meet high demand with low scaling tendency and easy maintenance.
    Close up of Syntegon membrane based WFI generator with multiple filter modules for lower WFI operating costs

    Significant OPEX reduction with cold storage and distribution

    Utilize ozon technology to store PW and WFI hygienic, safe and compliant at cold or ambient temperatures.
    14_Vetter
    Case Study

    Vetter expands PW capacity with Pharmatec generator

    Vetter Pharma-Fertigungs GmbH and Pharmatec successfully installed a new compact Purified Water generator in Langenargen – and laid the foundation for an extended partnership.

    value-icon-innovative-technologies
    Innovative Technologies We enable market leadership.
    Read the full story
    vetter

    Syntegon is the right partner for us to continue on our growth journey and shape the pharmaceutical industry of the future together.

    Dietmar Waizmann | Head of System & Service Media at Vetter

    Your strategic lifecycle partner for Pure Media utilities

    Technician inspecting stainless steel pure media utility line in pharmaceutical plant with Syntegon support

    Local Pure Media experts who keep your plant running
    Syntegon pure media skid with highlighted upgrade components illustrating future proof PW and WFI utilities

    Smart upgrades for future proof Pure Media systems
    Syntegon lifecycle support graphic with circular design visualizing ongoing service for pure media utilities

    Full lifecycle support for your Pure Media utilities

    Pure media knowledge hub

    Vetter secures future PW capacity with custom generator
    Vetter secures future PW capacity with custom generator

    See how a custom PW generator secures capacity, handles space limits, and delivers PW in WFI quality for growth.

    Download
    Expert article: energy efficiency in Pure Steam generation
    Expert article: energy efficiency in Pure Steam generation

    Read how small adjustments and a proactive consulting approach can lead to big savings in Pure Steam generation.

    Download
    Pure Media systems brochure
    Pure Media systems brochure

    Discover our complete portfolio of Pure Media systems for generation, storage and distribution.

    Download
    Pure Steam generation flyer
    Pure Steam generation flyer

    Find out how our compact PSG supports you in the efficient pharmaceutical-grade Pure Steam generation.

    Download
    WFI generation flyer
    WFI generation flyer

    Save energy in WFI generation with our innovative solutions based on membrane processes.

    Download

    Frequently asked questions

    Purified Water (PW), Water for Injection (WFI) and Pure Steam are essential utilities in pharmaceutical manufacturing. They are used for the preparation of the manufacturing equipment, for production and as ingredients for the pharmaceutical products themselves.

    Essential process steps in Pure Media generation are:

    • Pretreatment of the raw water supply
    • Purified Water (PW) generation
    • Production of Water for Injection (WFI) from PW
    • Pure Steam generation from PW
    • Storage and distribution of PW, WFI and Pure Steam
    • Regular sanitization of the entire infrastructure 

    Membrane-based WFI generation uses reverse osmosis, electrodeionization and ultrafiltration at ambient temperature. Distillation-based WFI relies on multi-column distillation and heating steam or electrical heating. Both approaches produce WFI that meets applicable pharmacopoeias, while membrane-based systems eliminate the need for steam generation equipment and can reduce energy consumption and floorspace compared to distillation-based systems. 

    Yes. The U.S. and Japanese Pharmacopoeias have long permitted alternatives to distillation for WFI generation. In 2017, the European Pharmacopoeia followed suit with the revision of monograph 0169, aligning with these standards and formally accepting membrane-based processes. WHO TRS 1025 additionally recognizes membrane processes as suitable methods.

    In October 2025, the Chinese Pharmacopoeia completed this global harmonization by aligning with U.S. and Japanese standards. Membrane-based WFI generation is therefore now accepted by all major pharmacopoeias and regulatory frameworks worldwide – provided systems are designed and operated to meet applicable regulatory requirements.

    Download portfolio overview

    Savings depend mainly on utility costs, production schedules, hot or cold supply and the reference distillation unit. Typically a MWFI system reduces the OPEX by 80-90 %.

    Download WFI flyer

    Our systems combine hygienic design, continuous operation and regular hot water or chemical sanitization to prevent biofilm formation. Pretreatment, membrane process steps and ultrafiltration remove particles, ions, microorganisms and endotoxins – with routine UF integrity testing verifying barrier performance. Integrated sensors continuously monitor conductivity, TOC and other critical attributes throughout the process, with online microbial counting available as an option.

    Syntegon membrane-based systems generate up to 20,000 l/h of PW and 13,000 l/h of WFI, with higher capacities available on request. Distillation-based systems deliver up to 12,000 l/h of WFI (up to 8,000 l/h with electrical heating) and up to 7,500 kg/h of Pure Steam (up to 800 kg/h with electrical heating), depending on configuration. This range covers everything from clinical plants to large commercial manufacturing facilities.

    Yes. Modular skids and compact layouts facilitate drop-in installation in existing technical areas with minimal structural modifications. In a recent project with Vetter, Pharmatec engineered a 10,000 l/h PW generator to fit a severely constrained room – splitting the frame for delivery and reassembling it on site. Similar engineering-to-order approaches allow you to expand your Pure Media capacity without major building changes.

    The right approach depends on energy costs, sustainability goals, existing utilities and required supply temperatures. Membrane-based WFI generation typically offers lower operating costs and a smaller footprint, while distillation-based systems provide a familiar hot process and the option to produce WFI and Pure Steam simultaneously. Syntegon experts evaluate your site specific demand profile, available utilities and site layout to recommend the most suitable technology mix for your GMP-compliant Pure Media infrastructure.

     

     

    Syntegon supports your Pure Media systems across every project phase – from process consulting, water analysis and system planning to lab support during development. Once in operation, services include spare parts management, field service, preventive maintenance, modernization, digital monitoring, remote support and operator training.

    This end-to-end lifecycle support keeps your GMP-compliant Pure Media utilities up and running, simplifies requalification and makes capacity upgrades and expansions easier to plan and execute. 

    Interested in Pure Media systems?

    Interested in Pure Media systems?

    Talk to our experts to discover the right solution for your needs.

    Learn more

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