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    Pharmaceutical freeze dryers

    Advanced automatic loading and unloading systems that fulfill the highest level of cleanliness and following strictly the first air principle.

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    Built for the pressures facing modern lyophilization

    Built for the most strict requirements from Top tier Pharmaceutical companies.

    Annex 1 compliance, high speed loading/unloading systems, cold shelf loading, solvents and high potent configurations, all integrated under RABS or Isolators.

    Fewer interventions. Every line, Every batch.

    How to connect freeze dryers to barrier systems under Annex 1?

    Connect freeze dryers to oRABS, cRABS or isolator lines for Annex 1 readiness.

    How to protect batch consistency at scale?

    Hold shelf temperature within 1°C of the shelf average to keep sublimation rates uniform.

    How to reduce manual interventions in changeovers and vial sampling?

    Automate loading and unloading to cut operator intervention in Grade A.

    Pharmaceutical freeze dryer line

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    Bioprocess equipment

    Prepares bulk drug substance upstream, preserving product integrity before formulation and fill.

    Formulation solutions

    Filling and Closing

    Fills and closes vials aseptically, setting up consistent conditions for freeze-drying downstream.

    Explore filling systems

    Freeze dryer

    Removes moisture under precise shelf temperature control, protecting batch consistency at scale.

    Explore freeze dryer solutions

    Inspection

    Detects defects in lyophilized containers with automated visual inspection, verifying product quality before release.

    Explore inspection machines

    Sterilizer

    Sterilizes vials and components before fill, reducing bioburden risk ahead of Grade A processing.

    Explore sterilization solutions

    Service Agreements - Ramp-Up Packages

    Our Service Agreement packages with defined ramp-up add-ons get you straight from performance qualification to commercial production, designed to help meet applicable regulations.

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    alf-with-telstar-fd

    Bioprocess equipment

    Prepares bulk drug substance upstream, preserving product integrity before formulation and fill.

    Formulation solutions
    alf-with-telstar-fd

    Filling and Closing

    Fills and closes vials aseptically, setting up consistent conditions for freeze-drying downstream.

    Explore filling systems
    alf-with-telstar-fd

    Inspection

    Detects defects in lyophilized containers with automated visual inspection, verifying product quality before release.

    Explore inspection machines
    alf-with-telstar-fd

    Service Agreements - Ramp-Up Packages

    Our Service Agreement packages with defined ramp-up add-ons get you straight from performance qualification to commercial production, designed to help meet applicable regulations.

    Learn more

    Explore the complete line

    Bioprocess equipment
    Filling and closing
    Freeze dryer
    Inspection
    Sterilizer
    Service Agreements - Ramp-Up Packages

    Find the right freeze dryer for your production stage

    Overall 4 Solutions
    Application stage
    Format coverage
    Automation level
    Barrier integration
    Cleaning approach
    Digital and validation support
    Benefits
    FreezeDryer_machine1-1
    LyoBeta
    Application stage
    R+D freeze dryer for advanced research centers, supporting scale-up
    Format coverage
    Vials and open flasks, 0.45 to 0.9 m² shelf area across 4 models
    Automation level
    Manual bench-scale operation, vial stoppering and spacing device standard
    Barrier integration
    Clean room configuration available as an option
    Cleaning approach
    Stainless steel AISI 316L chamber and condenser, fully accessible for cleaning
    Digital and validation support
    PLC touch-screen control standard, Lyosuite SCADA available as an option
    Benefits

    Best if you want:

    A compact R&D unit with production-matched heating and cooling rates

    2021_Lyozeta 10ST DH-RC con un Loading and Unloading System Lyogistics Integral RxR FP+RP
    LyoZeta
    Application stage
    Addressed to all pharmaceutical applications
    Format coverage
    Vials and bulk, multiple loading configurations
    Automation level
    Manual, semi-automatic and fully automatic Lyogistics options
    Barrier integration
    Isolator and O-RABS compatible, multiple layouts
    Cleaning approach
    Sanitary design per ASME BPE, dead leg control
    Digital and validation support
    Lyosuite SCADA control, 21 CFR Part 11 compliant
    Benefits

    Best if you want:

    Fast delivery and competitive pricing across formats

    04A
    LyoTris
    Application stage
    R&D, clinical trials, engineering and production
    Format coverage
    Vials and bulk, 1.02 m² usable shelf area
    Automation level
    Compatible with robotic loading and unloading systems
    Barrier integration
    Ready for cleanrooms and isolators
    Cleaning approach
    CIP validated with riboflavin test, SIP with saturated steam
    Digital and validation support
    PLC/SCADA control, CFR 21 Part 11 compliant, integrated filter testing
    Benefits

    Best if you want:

    A pilot unit that mirrors production behavior for scale-up

    LM200 with Lyogistics Zero and closed Gimbal door
    LyoMega
    Application stage
    High quality customized freeze dryer
    Format coverage
    Vials and bulk, engineered to requirements
    Automation level
    Fully automatic loading and unloading with Lyogistic Integral and Zero
    Barrier integration
    Installations designed for sterile production, ASME BPE compliant
    Cleaning approach
    Tri-Clamp sanitary connections, cGMP chamber design
    Digital and validation support
    Lyosuite SCADA control, 21 CFR Part 11 compliant
    Benefits

    Best if you want:

    Engineered-to-requirements freeze dryer with full automation

    internal-manifolds

    Download the pharmaceutical freeze dryer brochure

    Download to learn how to match freeze dryer scale to your production stage.

    • Compare R&D, pilot and production-scale freeze dryer configurations
    • See barrier and isolator integration options across the freeze dryer range
    • Review automation levels from manual to fully automatic loading
    Download

    Freeze dryer technology built to solve production problems

    logystic-telstar

    Automatic format changeover solution

    Smart Format switches vial sizes from 2R to 100R automatically.
    cpi-from-chamber

    Freeze dryer design modeled to your exact chamber

    CFD modeling calculates pressure, gas flow and ice deposition for your equipment.
    telstar-lyobeta

    Lab results that mirror production performance

    LyoBeta matches production heating and cooling rates for reliable scale-up.

    Your strategic lifecycle partner for pharmaceutical freeze dryers

    service-life-cycle
    Ready for everything from start to routine

    From installation to optimization Syntegon supports you with structured service packages, training and specialists for safe, stable and resilient production across the lifecycle.

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    service-life-uptime
    Secure availability every day

    Fast spare parts, qualified support and preventive maintenance help you avoid unplanned downtime, protect performance and keep daily operations reliable.

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    service-future-ready
    Make your line fit for tomorrow

    Scalable retrofits and data solutions help you adapt to new demands, improve OEE and keep your lines future proof across changing requirements.

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    Frequently asked questions

    Syntegon integrates pharmaceutical freeze dryers directly into complete RABS and isolator lines, including oRABS, cRABS and isolator configurations. This design approach helps fill-finish processes stay ready for current and future regulatory requirements, including EU GMP Annex 1.

    Temperature gradients across shelves are the most common cause of inconsistent cake structure and unpredictable reconstitution behavior in lyophilized vials.

    With a proper temperature mapping of all shelves during qualification, we ensure that the temperature homogeneity is achieved to ensure the highest quality for every batch. The use of wireless probes can also help ensure the repeatability batch after batch. See our solution with single use Sublime wireless probes.

    Lab-scale results transfer more reliably when the equipment shares core thermal characteristics with production units. LyoBeta's brazed plate heat exchangers deliver a 1°C per minute heating and cooling rate, aligning lab-scale thermal behavior with Syntegon's commercial freeze dryers. This alignment narrows the gap between R&D trials and full-scale manufacturing, reducing the risk of unexpected process behavior during scale-up. Syntegon cannot guarantee identical scale-up outcomes for every formulation, since product-specific factors also affect performance.

    LyoBeta is a compact R&D freeze dryer for research centers and clinical trials, with heating and cooling rates matched to production units. LyoTris bridges R&D and production as a pilot-scale cGMP unit. LyoZeta offers modular solutions across a wide range of sizes, with competitive pricing and fast delivery for pharmaceutical applications. LyoMega is engineered to requirements with several available options to fulfill the most strict specifications. Each model shares barrier system integration options, letting you scale from lab to commercial production within one connected freeze-drying approach. 

     

    Selection depends on your production stage and batch volume. Small freeze dryers like LyoBeta suit R&D, clinical trials and small batch production, with compact footprints and manual bench-scale operation. Medium options like LyoTris fit pilot-scale cGMP production, bridging R&D and commercial output. LyoZeta and LyoMega range are prepared to fulfil large size batches. Reviewing your batch size and vial type, there will be a perfect model for every application.  Reviewing your batch size, format range and automation needs against the comparison table on this page helps narrow the right fit.

    Interested in a pharmaceutical lyophilizer?

    Interested in a pharmaceutical lyophilizer?

    How can we help you?

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