Pharmaceutical sterilization

pharmaceutical sterilisation process - syntegon

Sterilization of pharmaceutical products and equipment

Liquid pharmaceuticals, their containers, and process equipment share a common trait: they all require reliable sterilization solutions to ensure maximum pharmaceutical safety. The Syntegon subsidiary Schoeller-Bleckmann Medizintechnik (SBM) offers a vast portfolio of both individually customizable and standardized, yet modularly configurable autoclaves. Vacuum-steam, steam-air mixture, a combined process, or hot water shower sterilize porous loads and liquids in open, semi-sealed, or closed containers effectively, optimize your energy requirements and support you in reproducible terminal and equipment sterilization.

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Key benefits

Wide process range

different sterilization methods cater to the varying treatment requirements of porous goods and liquids

Standardized set-up

all SBM sterilization machines have a flexible recipe editor for customized processes and comprise high-quality, globally available components

Hygienic design

our sterilization equipment comprises maintenance and particle-free encapsulated door drives for clean room applications, and many further hygienic features

Pharmaceutical sterilization machines – our solutions

ADV vacuum-steam sterilization

Pharmaceutical manufacturers in need of flexible and effective sterilization can rely on the vacuum-steam process from Syntegon. The ADV range of autoclaves utilizes the direct inflow of clean steam, which makes it ideally suited for the sterilization of porous and solid equipment, as well as for liquids in open containers up to 50 milliliters. The process is based on air evacuation from the pressure vessel, enabling saturated steam to penetrate the cavities of porous items like machine parts or rubber stoppers. As a particularly versatile system, the ADV supports vacuum-steam sterilization processes in production plants, research facilities and laboratories, also covering final process steps like vacuum drying or jacket cooling.

Benefits:

Flexible product loading for best use of the available space
Automatic in-line filter sterilization
Possibility to integrate steam/air mixture process

SDR steam/air mixture sterilization

In 1970, the steam/air mixture process revolutionized pharmaceutical sterilization. Developed and patented by Schoeller-Bleckmann Medizintechnik (SBM), the SDR range sterilizes pharmaceutical liquids in open, semi-sealed and fully closed containers such as vials and pre-filled syringes, as well as mono- and multi-chamber bags. The sterilization machine ensures a homogenous temperature distribution, rapid cooling and manufacturers can remove products in a dry condition at the end of the cycle. Like all Syntegon autoclaves, the SDR includes a flexible recipe editor as well as high-quality standard components to secure a versatile and safe production.

Benefits:

Patented sterilizing method
Powerful radial fans and air baffles for fastest possible cycle times
Optimized flow guidance system for improved temperature distribution

SWS hot water shower sterilization

Effective sterilization of liquids in 100% closed containers such as IV solution bags calls for Syntegon’s SWS range. The terminal sterilizer uses a continuous homogeneous superheated water shower for the efficient treatment: a unique water distribution concept achieves ideal temperature distribution, while the special design optimizes the energy demand for heating and cooling. The system’s high-performance pumps enable elevated circulation rates and a subsequent uniform temperature increase, reducing the thermal load on temperature-sensitive products to a minimum.

Benefits:

FDA-compliant double tube sheet heat exchangers
Optimum temperature distribution even in very large systems
Minimized thermal stress for temperature-sensitive liquid loads

SBM Essential Line – the modular series

The sterilizers of the SBM Essential Line with their common, standardized base offer pharmaceutical manufacturers short delivery times and cost-effectiveness combined with a wide range of configuration options. They sterilize both porous and solid equipment as well as liquids in containers such as vials, ampoules, or syringes using a vacuum-steam (ADV), steam-air mixture (SDR) or combined (SDT) process. The basic pressure vessel is available in twelve sizes and usable chamber volumes from around 200 to 3,500 liters. Further options such as the high-pathogen program or automatic inline filter sterilization provide additional product safety. Various software configurations or the optional air detector module ensure easy handling.

Standardized base for cost-effectiveness and short delivery times
Optional air detector module for ADV and SDT sterilizers for effortless Annex 1-compliance
High-performance control system with WinCC visualization as standard

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More than 60% of all disposable contact lens worldwide are sterilized in a SBM autoclave

20% energy saving by the special chamber sump design at our hot water shower sterilizers

Production and development of sterilizers for the pharmaceutical industry since 1972

Over 1500 installed units in more than 50 countries worldwide

Service Agreements

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Digital Solutions

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Parts

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Maintenance

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Technical Support

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Modernizations

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Training

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Expert Services

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About us

In-house technology: our long-standing experience in pharmaceutical sterilization processes has enabled us to develop industry-leading solutions.
Container flexibility: Syntegon sterilization equipment addresses the requirements of different sizes and types of pharmaceutical containers.
Safe sterilization: all process plants ensure high-quality sterilization without compromising product quality.

There’s more than one approach to effectively sterilizing pharmaceutical containers and equipment. We have the experience and know which process and sterilization media suit your requirements – from powerful vacuum to hot water, steam and air. As a pioneering sterilization equipment manufacturer, we not only focus on efficient sterilization. We always have the safety of containers and products in mind, which is why our systems ensure gentle treatment for overall high quality.

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years of experience

patents and patent applications

machines installed world-wide

locations

Pharmaceutical sterilization downloads

Sterilization Brochure

The key facts about SBM and our portfolio speak for themselves. Take a look at our brochure for more details.

Flyer Pasteurisation

SBM offers customized solutions for the expensive and challenging pasteurization process, meeting specific product needs.

Automatic Calibration

Learn more about the automatic calibration of the temperature sensors in your SBM sterilizers.

Sterilizer Essential Line

Learn more about the SBM sterilizer esential line.

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Pharmaceutical sterilization

Sterilization of pharmaceutical products and equipment

Key benefits

Wide process range

Standardized set-up

Hygienic design

Pharmaceutical sterilization machines – our solutions

SBM Essential Line – the modular series

Interested?

Service Agreements

Digital Solutions

Parts

Maintenance

Technical Support

Modernizations

Training

Expert Services

Why choose a Syntegon pharmaceutical sterilization solution?

About us

Pharmaceutical sterilization downloads

Read our latest pharma news

Interested in pharmaceutical sterilization solutions?

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