Pharmaceutical filling machines

Just like the multitude of pharmaceutical products on the market, sterile filling technologies each serve different purposes. With Syntegon’s wide selection of filling technologies, you can be sure to meet the most pressing challenges: from filling highly potent pharmaceuticals to ensuring sterile operations and full process data transparency, our solutions support first-class liquid filling.

We combine well-established technologies with innovative digital and automation solutions, allowing you to achieve maximum yields with high dosing accuracy.

Key benefits

Unmatched variety

We offer the widest range of sterile filling technologies for different applications, including suspensions, viscous liquids, and aqueous solutions.

High dosing accuracy

Our state-of-the-art filling systems comprise sensors to measure volume flows and precisely dose filling quantities.

Thorough testing

Each technology undergoes rigorous trials with original products or placebos at our lab to ensure full functionality.

Peristaltic pump

Rolling diaphragm pump

Rotary valve piston pump

Smart Pump

Mass-flow filling

Time-pressure filling

Combi filling

Filling biopharmaceutical active ingredients requires a true alternative to conventional pumps. As one of the most user-friendly filling systems available, our peristaltic technology combines precision and product safety. Apart from the tubes, equipment components do not come into contact with the product, which makes the peristaltic pump safe and predestined for single-use filling systems. Filling volumes typically vary between 50 microliters and three milliliters, offering you a flexible approach for the secure filling of highly potent pharmaceuticals.

Benefits

Housing, pump head and rotor with rollers made of stainless steel (316L)
Particularly suitable for aqueous solutions and biotech products
Completely exchangeable product path (single-use tubing)

The system is a true globetrotter, as it has made its way across continents. While it was largely used for filling operations in the US, it has now also become a sought-after technology in other regions. It reliably transports the product through the pump chamber via a rolling diaphragm, enabling closed, low-shear filling. Especially water-like liquids, which prove challenging because of cross-contamination, leakage, cleaning and sterilizability, are filled in a highly safe manner. Our rolling diaphragm pump also supports a flexible, small-batch production, since it is available as a stainless steel and single-use variant.

Benefits

Closed filling system
Easy to clean and sterilize
Exactly repeatable filling volumes

If you are looking for a true all-rounder, the rotary valve piston pump is an ideal choice, as it allows to precisely fill both aqueous solutions and highly viscous liquids. The easy-to-handle and precise system is especially suited for filling products that are not shear-sensitive. Besides its very wide range of applications, the filling system offers flexibility in terms of design: it is available as a stainless steel and a ceramic variant. Moreover, the rotary valve piston pump allows easy integration with the Smart Pump, our Industry 4.0 solution.

Benefits

Servo drive for particularly high precision
Simple assembly, few seals
Easy to clean and sterilize by CIP/SIP

Our innovative Smart Pump lays the basis for added process data transparency. Latest RFID technology transfers critical parameters like cleaning status, pump position and correction value from the piston pump to the filling machine. To this effect, each filling point is provided with a RFID reader. Operators can visualize the data on the filling machine’s control panel. All information is stored on the integrated RFID tag.

Benefits

Early error detection
Process safety
Reproducible parameters

Precise filling operations call for mass-flow technology. The closed system is equipped with sensors that measure the volume flow, making sure that the system precisely doses the filling quantities. Besides filling accuracy, mass-flow offers the possibility to handle hot or cold filling, which makes it particularly suited for processing e.g., X-ray contrast media.

Benefits

Short CIP/SIP times
Very precise dosing
Integrated 100 % in-process control (IPC)

Demanding products like suspensions or crystallizing liquids are best filled in a closed, easy-to-clean system like Syntegon’s time-pressure filling system. Specific algorithms significantly increase filling accuracy. From a mechanical perspective, time-pressure filling achieves maximum product yields thanks to filling sections that can be fully emptied.

Benefits

High precision and productivity
User-friendly overall geometry
Easy assembly and format changes

Filling more than one product with different properties doesn’t necessarily require different systems. Syntegon’s combi approach provides the required flexibility on a single platform: it combines up to four filling stations (peristaltic, rotary valve piston and rolling diaphragm pump, time-pressure filling) that support frequent but short product changeovers. The patented, compact filling station is particularly suitable for setting with low space and high flexibility requirements.

Benefits

Variable number of filling stations
Flexible and space-saving layout
Suited for stainless steel or single-use systems

Interested?

Get in touch with us.

Service Agreements

We support you throughout the entire machine life cycle, from spare parts management to digital line optimization. Service Agreements are a key element of our portfolio structure. Together, we tailor our solutions to your individual needs. Our global network of experts supports you with maintenance planning, technical support as well as operator training and end of life services. With our digital solutions, you gain control over your production processes and create transparency on product and machine data anytime, anywhere.

Maintenance & Support

Spare Parts

About us

Patented technologies: With the rolling diaphragm pump and combi station, Syntegon offers innovative solutions that have been developed in-house.

Widest selection: Our portfolio is the largest on the market, providing customers with an opportunity to fully customize their operations.

Digital solutions: Our systems include digital technologies to support full process data transparency.

years of experience

patents and patent applications

machines installed world-wide

locations

Downloads

Smart Pump

The innovative filling solution

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Pharmaceutical filling systems

Key benefits

Unmatched variety

High dosing accuracy

Thorough testing

Pharmaceutical filling systems & features

Peristaltic pump

Rolling diaphragm pump

Rotary valve piston pump

Smart Pump

Mass-flow filling

Time-pressure filling

Combi filling

Interested?

Service Agreements

Maintenance & Support

Spare Parts

Why choose a Syntegon filling system?

About us

Downloads

Our customers are also interested in

Interested in pharmaceutical filling systems?

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