Pharmaceutical Filling Machines

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Just like the multitude of pharmaceutical products on the market, sterile filling technologies each serve different purposes. With Syntegon’s wide selection of filling technologies, you can be sure to meet the most pressing challenges: from filling highly potent pharmaceuticals to ensuring sterile operations and full process data transparency, our solutions support first-class liquid filling.

We combine well-established technologies with innovative digital and automation solutions, allowing you to achieve maximum yields with high dosing accuracy.

Key benefits

Unmatched variety

We offer the widest range of sterile filling technologies for different applications, including suspensions, viscous liquids, and aqueous solutions.

High dosing accuracy

Our state-of-the-art filling systems comprise sensors to measure volume flows and precisely dose filling quantities.

Thorough testing

Each technology undergoes rigorous trials with original products or placebos at our lab to ensure full functionality.

Filling biotechnologically produced active ingredients places special demands on pump technology.

Our user-friendly peristaltic pump ensures gentle operation and precise dosing of cost-intensive products. As it does not require any format parts except for the hoses, the system can be operated with one hand using clip connectors. Thanks to these versatile features, the peristaltic pump is ideal for the use in barrier systems according to the EU GMP Annex 1 guidelines.

What’s more, this pump type is particularly suited for single-use applications.

Benefits:

Ideal for shear-sensitive products
Easy handling
No format parts

The rotary valve piston pump is extremely flexible and can be used for a wide range of applications. Its volumetric operating principle ensures high dosing accuracy for both aqueous and highly viscous liquids.

The ceramic version of the pump can also be used to fill hot and abrasive products.

The optional Smart Pump variant ensures maximum process reliability and precision while opening up new possibilities for predictive maintenance.

Benefits:

Wide range of applications
High flexibility
Available as stainless steel and ceramic versions

The rolling diaphragm pump combines the advantages of the peristaltic and rotary valve piston pumps. It offers gentle product handling thanks to the absence of shear contours combined with the dosing precision of a volumetric filling system.

The pump’s flexible diaphragm gently conveys the product through a piston and the pump body.

The technology is available both as a CIP/SIP and a single-use version to meet very demanding production requirements.

Benefits:

Innovative product conveying concept
CIP/SIP, stainless steel, or single-use version
Gentle product handling, perfectly suited for biopharmaceuticals

The increasing demand for space-saving machines with barrier systems requires ever more compact filling systems. This is especially true for the high-performance range and the use of a large number of filling stations. Thanks to its space-saving design, the time-pressure filling system ideally meets these requirements.

In connection with a minimum of moving mechanical parts, an intelligent algorithm enables gentle and precise filling.

Benefits:

Highly compact
Optimal accessibility
Easy format changeover

A mass-flow sensor operating according to the Coriolis principle in each filling section ensures 100% in-process control and precise filling operations.

This sophisticated sensor technology further enables the system to manage demanding tasks such as hot and cold filling.

Benefits:

100% in-process control (IPC)
Particularly suited for cold or hot products
Preferred system for X-ray products

Our innovative Smart Pump provides full transparency. State-of-the-art RFID technology transmits pump-specific parameters such as cleaning status, serial number, and correction values to the filling machine via a reading device. This allows operators to read the visualized data on the machine’s HMI conveniently and reliably.

Benefits:

Process reliability
Effectiveness
Validation and traceability

Filling different products with specific properties often requires more than one filling system. Our patented combi filling stations can combine several filling systems on one machine, allowing you to flexibly adapt your production line at any time.

Benefits:

Up to four filling systems on one filling station
Patented design
Suitable for stainless steel and single-use systems

Syntegon offers single-use technology and revolutionizes the filling of sterile, liquid pharmaceuticals. The single-use assembly known as PreVAS in the United States and stands for pre-validated, pre-assembled, pre-sterilized and is a fully customizable single-use fluid path with an extensive list of validations performed according to industry regulations. These assemblies come fully assembled and gamma-sterilized and are ready to use straight out of the box. Single-use assemblies can be used with most Syntegon filling machines and supports both Syntegon’s peristaltic pumps and single-use rolling diaphragm pumps. PreVAS provides an efficient production process with the swift change over between batches, the time to market is significantly reduced and allows for a high degree of production flexibility.

Benefits:

Elimination of cleaning and sterilization of reusable equipment
Elimination of cross-contamination between batches
Reduced risk of operators exposure to potent products

Interested?

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Parts

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Maintenance

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Technical Support

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Modernizations

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Training

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Expert Services

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About us

Patented technologies: With the rolling diaphragm pump and combi station, Syntegon offers innovative solutions that have been developed in-house.

Widest selection: Our portfolio is the largest on the market, providing customers with an opportunity to fully customize their operations.

Digital solutions: Our systems include digital technologies to support full process data transparency.

years of experience

patents and patent applications

machines installed world-wide

locations

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Smart Pump

The innovative filling solution

Filling Systems Applications

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