Automatic Capsule Filling Machine

Automatic capsule filling machine series for all requirements

The future-proof GKF Performance series provides highly flexible machine platforms that meet all demands for the highest pharmaceutical production standards. Based on more than 50 years of experience in capsule filling, this automatic capsule filling machine series has a special focus on complex dosing processes, as well as on optimal productivity and fully integrated inspection technologies. All machines from the Performance series are also available with the Syntegon ProTect and HiProTect containment concept, ensuring the highest operator protection.

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Key benefits

Versatile and flexible

Different dosing options for your products, with a special focus on combination dosing

Integrated inspection

Our automatic capsule filling machine series provide sampling and 100% monitoring with inspection systems

Modular machine design

Experience high flexibility with minimized changeover and cleaning times, as well as optimal productivity

automatic-capsule-filling-machine-GKF-60

GKF 60 automatic capsule filling machine

R&D automatic capsule filling machine – Takes your molecule to production.

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GKF 720 automatic capsule filling machine

One platform for all requirements – from galenical development (R&D set-up) to small scale batch manufacturing.

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GKF 2600 automatic capsule filling machine

Fulfills the increasing requirements for large batch production, thanks to it‘s great flexibility in regard of dosing and inspection technologies.

GKF 60

Our GKF 60 automatic capsule filling machine offers high versatility and state-of-the-art quality control features for early R&D stages. The platform can accommodate both established and new dosing technologies at outputs of up to 3,600 capsules per hour. It also provides a unique machine cabin with a laminar air flow concept.

GKF 720

At output rates of 3,000 to 43,500 capsules per hour, the GKF 720 automatic capsule filling machine is ideal for scale-up from R&D to small batch production. It provides various inspection technologies and very flexible dosing possibilities. Moreover, it features a modular design and flexible plug-in station.

GKF 2600

The modular GKF 2600 automatic capsule filling machine fulfils all needs for large batch production at up to 156,600 capsules per hour. The platform provides great flexibility in dosing and inspection technologies. It can easily be tailored to your product specifications and quality control (QC) requirements.

Filling technologies and dosing options

The automatic capsule filling machines from the GKF Performance series achieve precise filling results from free-flowing to cohesive powders, pellets and (micro-) tablets, as well as for products of a liquid or pasty nature. Besides dedicated filling applications for micro dosing of inhalable products, we offer customized solutions for critical product properties and combinations.

Dosing options

Vacuum-wheel for DPI and API dosing provides high accuracy for small quantities
Powder dosing by tamping pin principle with slide-gate technology or vacuum dosing via dosator technology
(Micro-) tablet dosing with highest flexibility in various count fillings

Integrated inspection technology

The GKF Performance series offers various inspection technologies. An integrated and fully automatic capsule-weighing unit IPC (In-Process Control) provides a statistical overview of the capsule gross and net weight. Syntegon further offers an integrated net weight detection system (NWDS) for 100 % net weight determination. To verify the right count and accuracy during (micro-) tablet dosing, a light sensor can be implemented.

Benefits

Cross reference check of system integrated inspection technologies, e.g. NWDS
Precise 100 % weighing of all capsules via KKE checkweigher
All recorded data fully integrated in batch report

APD Technology

Syntegon has developed a new Quality by Design approach: the APD (Automated Process Development) technology to determine and automatically adjust the optimal parameters for your capsule filling processes. The combination of systematic planning (DoE) with automatic test setup on a GKF capsule filler is a unique and patented technology that enables you to perform many experiments in a short time. It allows a broad screening to identify interactions between process parameters and to optimize yield, quality and robustness.

Process Analytical Technology (PAT Classic)

According to the FDA, the goal of PAT is to enhance understanding and control the manufacturing process. Quality cannot be tested into products; it should be built-in by design. Syntegon has developed a new approach that can be integrated into the encapsulation process. It tackles your most prominent issues and provides quality assurance during the entire hard capsule filling process. Our “PAT Classic” system provides you with detailed insights into critical process parameters und helps you to achieve a safe, reliable and robust production.

Benefits

High-precision quality assurance during the entire filling process
Powder bed height detection to achieve highest dosing accuracy and lowest residual waste
Transfer force detection to avoid mechanical damages
Closing force detection to identidy defects, e.g. capsule breakage, cracking, splicing and deformation

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Technical data of our GKF Performance series

Technical data overview

	GKF 60	GKF 720	GKF 2600
Output	3,600 caps/h	3,000 up to 43,500 caps/h	156,600 caps/h
Segment bores	1	5	18
Machine cycles	Max. 60 cycles/min	Max. 145 cycles/min	Max. 145 cycles/min
Dimensions (HxWxD)	1,900 x 1,000 x 900 mm	3,490 x 3,133 x 2,101 mm	3,548 x 3,178 x 2,436 mm
Connected voltage	According to customer specification	380-480 V, 50/60Hz Special voltages on request	380-480 V, 50/60Hz Special voltages on request

Service Agreements

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Digital Solutions

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Parts

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Maintenance

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Technical Support

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Modernizations

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Training

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Expert Services

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About us

Processing and packaging for a better life – this is what our employees work for every day. Looking back on a 160 years of experience, the portfolio of intelligent, innovative and reliable solutions help our customers in the global pharmaceutical and food industries to improve people‘s life.
With 1,100 service experts and a comprehensive service portfolio throughout the entire machine lifecycle from spare parts management to digital line optimization, Syntegon lays the foundation for smooth production processes for all customers.

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years of experience

patents and patent applications

machines installed world-wide

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Why capsule sealing?

Capsule sealing with banding technology ensures the highest product quality and prevents liquid-filled capsules from leakage. Banding also provides an additional measure for anti-counterfeiting of capsules filled with powder or other components. Sealing provides an enhanced safety measure to meet regulatory requirements. Our Syntegon GKB 2100 banding machine can handle both hard gelatine and HPMC (plant-based) capsules.

The Syntegon GKB 2100 banding machine

The new GKB 2100 features a particularly robust and flexible process, combined with the highest yield and maximum process stability. The focus is on user-friendliness, as well as very good accessibility for cleaning and easy format part changeovers. Our banding machine achieves an output of up to 125,000 capsules per hour.

Automatic capsule filling machine downloads

GKF 60

R&D capsule filling machine – takes your molecule to production.

GKF 720

A GKF capsule filling machine from galenical development (R&D set-up) to small-scale batch manufacturing.

GKF 2600

The modular capsule filling machine fulfills the increasing requirements for large batch production thanks to its flexibility in dosing and inspection technologies.