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    RTU syringe filling for Annex 1 compliant aseptic processing

    Keep RTU syringe lines running at target speed with precise filling and closing that reduce rejects and unplanned interventions.  

    Explore our RTU syringe solutions

    Overall 8 Solutions
    Output performance
    Format range
    Special features
    Changeover
    Filling systems
    Container types
    Barrier technologies and line integration
    Benefits
    Versynta_microbatch
    Versynta microBatch
    Output performance
    Up to 500/h (nest)
    Format range
    Syringes 0.5–20 ml, plus vials 2R–50R, cartridges 1-10ml
    Special features
    Gloveless isolator, robotic cell, 100% in‑process control
    Changeover
    Fast batch‑to‑batch changeovers
    Filling systems
    Peristaltic, rolling diaphragm
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    Gloveless isolator, integrated air management
    Benefits

    Best if you want:

    • a gloveless robotic micro‑batch cell
    • short biodecontamination and fast changeovers
    • minimized product loss 
    Brochure
    1080x720_VersyntaFFP
    Versynta FFP
    Output performance
    Up to 3,600/h
    Format range
    Syringes 0.5–10 ml, vials 2R–50R, cartridges 1–10 ml
    Special features
    100% in‑process control, isolator with integrated air management
    Changeover
    Size‑parts only, no module exchange
    Filling systems
    Peristaltic, piston, rolling diaphragm; vacuum filling and stoppering
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    Isolator with integrated air management
    Benefits

    Best if you want:

    • size‑part only changeovers across containers
    • 100% in‑process control on all formats
    • easy lyophilization integration
    Brochure
    1080x720_FXS2052
    FXS 2052
    Output performance
    Low to medium output rates
    Format range
    Syringes 0.5–20 ml, Ø 6.85–22.05 mm
    Special features
    Peristaltic pump, vacuum stoppering, single‑use possible
    Changeover
    Easy size‑part changeover to vacuum stoppering
    Filling systems
    Peristaltic, single‑use possible
    Container types
    Syringes
    Barrier technologies and line integration
    RABS, cRABS, isolator
    Benefits

    Best if you want:

    • a space‑saving inline layout
    • shorter nest exchange via special nest feeding
    • an entry‑level option for emerging markets
    Brochure
    1080x720_FXS3100
    FXS 3100
    Output performance
    Up to 355/min
    Format range
    Syringes 0.5–20 ml (50 optional), height to 142 mm (162 optional), Ø 6.85–22.05 mm (29.6 optional)
    Special features
    Vacuum filling and vacuum stoppering options
    Changeover
    Easy size-part changeover to vacuum stoppering
    Filling systems
    Peristaltic, vacuum filling and stoppering
    Container types
    Syringes
    Barrier technologies and line integration
    RABS, cRABS, isolator
    Benefits

    Best if you want:

    • operation from one side in a slim design
    • an upgrade path to high‑speed execution
    • vacuum filling and stoppering options
    Brochure
    1080x720_FXS5100
    FXS 5100
    Output performance
    Up to 600/min
    Format range
    Syringes 0.5–20 ml (50 optional), height to 142 mm (162 optional), Ø 6.85–22.05 mm (29.6 optional)
    Special features
    Continuous filling and closing during nest change, precise transport
    Changeover
    Easy size-part changeover to vacuum stoppering
    Filling systems
    Peristaltic, vacuum filling and stoppering, gassing
    Container types
    Syringes
    Barrier technologies and line integration
    RABS, cRABS, isolator
    Benefits

    Best if you want:

    • continuous filling during nest change
    • precise, adaptable transport and needle motion
    • operation from one side
    Brochure
    1080x720_FXSCombi-1
    FXS Combi
    Output performance
    Low, medium or high output rates
    Format range
    Syringes 0.5–20 ml (50 optional), vials 2R–20R (25R, 30R optional), cartridges 3–10 ml
    Special features
    Fully automatic in‑process control, vacuum filling and stoppering
    Changeover
    Easy, quick format changes
    Filling systems
    Suited for Syntegon filling technologies, vacuum filling and stoppering
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    RABS, cRABS, isolator
    Benefits

    Best if you want:

    • one machine for syringes, vials and cartridges
    • quick format changes with integrated capping
    • flexible line integration
    Brochure
    1080x720_MLDAdvanced
    MLD Advanced
    Output performance
    Up to 400/min
    Format range
    Syringes 0.5–10 ml, plus vials 2R–30R, cartridges 1–3 ml
    Special features
    100% in‑process control, modular conveyor, tub and nest handling
    Changeover
    Tool-free changeover
    Filling systems
    Multiple options including vacuum filling
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    Annex 1 compliant, flexible L or U layouts
    Benefits

    Best if you want:

    • high‑speed syringes with 100% IPC
    • add stations via modular conveyor
    • flexible L or U layouts
    Brochure
    1080x1080_syntiso-1
    SynTiso
    Output performance
    Up to 600/min
    Format range
    Syringes 0.5–20 ml, vials 2R–50R, cartridges 1–20 ml
    Special features
    Gloveless in‑air isolator, frictionless transport, 100% in‑process control
    Changeover
    Automated aseptic set‑up functions
    Filling systems
    Peristaltic, piston, time‑pressure, vent tube or vacuum stoppering
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    In‑air gloveless isolator, RackSter sterile parts transfer, connects lyophilization and inspection
    Benefits

    Best if you want:

    • an in‑air gloveless isolator with frictionless transport
    • RackSter sterile parts transfer and BFPC integration
    • OEE improvement >35%
    Brochure

    RTU syringe standouts: gloveless assurance, fast changeover, proven scale

    1080x1080_Syn058

    600 syringes/min with 100% in‑process control

    Verify every unit at speed in a gloveless isolator.
    1080x1080_FFP

    Size‑part only changeovers on a compact RTU syringe line

    Switch formats without module swaps and keep the barrier closed.
    1080x1080_FFP2

    Output scale from micro batches to 600/min

    Match capacity to real demand without oversizing assets.

    Explore related solutions for RTU syringe filling

    1080x720_DSF0100
    Filling systems
    1080x720_VisualInspection-1
    Visual inspection

    Your strategic lifecycle partner for RTU filling

    service-life-cycle
    Lifecycle and Annex 1 consulting for RTU lines

    Plan RTU projects with experts who know Annex 1 from URS to qualification. Service agreements, training and digital support keep performance stable across the lifecycle. 

    Learn more
    service-life-uptime
    Secure availability – every day

    Fast spare parts, qualified support, and preventive maintenance help you avoid unplanned downtime, protect performance, and keep daily operations reliable.

    Learn more
    service-future-ready
    Make your line fit for tomorrow

    Scalable retrofits and data solutions help you adapt to new demands, improve OEE, and keep your lines future-proof across changing requirements.

    Learn more
    Featured_Download_Teaser_RTU

    Plan your RTU filling portfolio with confidence

    See all Syntegon RTU filling options by output and container.

    • Match batch size to output
    • Compare RTU machines for each container
    • Check Annex 1 ready and IPC features
    Download
    1080x1080_SyntisoFrosted
    Innovation Spotlight

    SynTiso gloveless RTU line for high speed filling

    See how SynTiso combines a gloveless isolator and up to 600 containers per minute for large RTU campaigns.

    Explore SynTiso

    Ready to use filling knowledge hub

    Explore all RTU filling machines
    Explore all RTU filling machines

    Get an in-depth overview of advanced RTU filling solutions designed for syringes, vials, and cartridges.

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    Explore SynTiso – the next evolution.
    Explore SynTiso – the next evolution.

    Learn more about SynTiso, the gloveless solution, that combines regulatory compliance with cutting-edge technology.

    Download
    Small and micro batch whitepaper
    Small and micro batch whitepaper

    Learn how small and micro batches are changing pharmaceutical processes.

    Download

    Frequently asked questions

    The portfolio spans small, medium, and high output. Examples:

    • microBatch up to 500/h

    • Versynta FFP up to 3,600/h

    • FXS 3100 up to 355/min

    • MLD Advanced up to 400/min with 100% in-process control 

    • FXS 5100 up to 600/min

    • SynTiso up to 600/min with 100% in‑process control

    Coverage depends on the platform. microBatch handles syringes 0.5–20 ml. Versynta FFP 0.5–10 ml. FXS family up to 0.5–20 ml with options to 50 ml depending on model. MLD Advanced 0.5–10 ml . SynTiso 0.5–20 ml. Confirm final ranges during configuration.

    Barrier systems and automation reduce Grade A interventions. Gloveless isolators and 100% in-process control are available on several platforms. SynTiso is Annex 1-compliant with an in-air gloveless isolator. Other platforms offer RABS or isolator options.

    Download portfolio overview

    Yes. microBatch processes syringes, vials and cartridges in nests. Versynta FFP is ready for all container types with size-part only changeovers. FXS Combi handles all three on one machine. MLD Advanced and SynTiso run syringes, vials and cartridges at higher outputs.

    Find out more

    Options by platform include peristaltic, piston, rolling diaphragm or time-pressure filling, vacuum filling and vacuum stoppering and vent-tube stoppering on SynTiso and MLD Advanced. Single-use filling systems are available on select models such as FXS 2052 and Versynta FFP. Availability depends on configuration.

    RTU equipment processes pre-sterilized, nested containers from qualified suppliers. This reduces in-house preparation compared with bulk components and lets teams focus on filling and closing. Exact supplier steps and documentation follow the component qualification package.

    Yes. SynTiso connects upstream and downstream processes such as lyophilization and inspection and supports automated sterile parts transfer with RackSter. Versynta FFP offers easy freeze dryer integration inside the isolator.

    Interested in filling RTU cartridges, syringes & vials?

    Interested in filling RTU cartridges, syringes & vials?

    Talk to a Syntegon expert to learn more about RTU filling solutions.

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