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formulation-systems
Formulation Systems

The new, cost-efficient SVP Essential is a fully automated, ready-to-use system to produce simple parenterals such as analgesics, insulin, and generic drugs.

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cleaning
Cleaning

Syntegon’s portfolio of compact pharmaceutical cleaning systems for the low, medium and high output ranges prevents potentially harmful substances from compromising operator and patient safety.

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depyrogenation
Depyrogenation

Thanks to a wide range of depyrogenation tunnels and related sterilization technologies, we provide versatile solutions for an effective and sustainable pre-treatment of liquids in open, semi-sealed or closed containers.

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filling-and-closing
Filling and Closing

A wide range of technologies, including valve piston and peristaltic pump, mass-flow and time-pressure filling, make sure you can fill your products in a highly customized way. Tool-less format changes and filling stations with a variable number of filling heads increase the flexibility of your filling processes.

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barrier-systems
Barrier Systems

Syntegon has established a comprehensive portfolio, including open RABS, closed RABS, containment and isolator systems.

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sterilization
Sterilization

Versatile sterilization solutions for an effective treatment of porous loads and liquids in open, semi-sealed or closed containers.

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inspection
Inspection

State-of-the-art technologies for visual inspection and container closure integrity testing (CCIT), including high voltage leak detection (HVLD), static division (SD) and headspace analysis (HSA).

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pen-assembly
Pen assembly

Our modular assembly systems with scalable levels of automation reliably support the production of standard 4-piece disposable pens and come in different designs according to your desired production rates.

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The right match
for your needs

These solutions meet your cartridge fill finish requirements

Cartridge processing is a complex task that calls for support from the number one equipment provider. If you are looking for the highest performance and precision, our cartridge filling and capping portfolio has a lot to offer for all output ranges: from accurate positioning under the working stations to low-particle capping with patented technologies, from high-quality operations to a modular and space-saving design.

formulation-systems

Formulation Systems


When it comes to bioprocessing, the systems from Syntegon’s subsidiary Pharmatec flexibly support the production of small and large volume parenterals (SVP/LVP) and infusions (IV). The process solutions comprise modular set-ups of temperature-controlled stainless-steel tanks that can be assembled to meet customer-specific settings. The new, cost-efficient SVP Essential is a fully automated, ready-to-use system to produce simple parenterals such as analgesics, insulin, and generic drugs.

cleaning

Cleaning


Before and after filling, vials, ampoules, syringes, and cartridges need to undergo a crucial process step. Thorough internal and external cleaning is necessary to remove product residues and other contaminants from the containers’ inner and outer sides. As such, cleaning prevents potentially harmful substances from compromising operator and patient safety. Syntegon’s portfolio of compact pharmaceutical cleaning systems for the low, medium and high output ranges support manufacturers in reaching this goal. The hygienic and ergonomically designed solutions allow to clean a wide variety of containers, with special emphasis on fast and easy operations.

depyrogenation

Depyrogenation


Whether you are filling liquid pharmaceuticals into ampoules, vials, injection and infusion bottles, cartridges or syringes: the reliable pre-treatment of containers significantly contributes to product safety. Thanks to a wide range of depyrogenation tunnels and related sterilization technologies, we provide versatile solutions for an effective and sustainable pre-treatment of liquids in open, semi-sealed or closed containers. Dry heat, vacuum, steam/air mixture and hot water shower sterilization help you achieve reproducible treatment quality while optimizing your energy requirements.

filling-and-closing

Filling and closing


Our filling systems for pre-sterilized packaging combine flexibility and precision: a wide range of technologies, including valve piston and peristaltic pump, mass-flow and time-pressure filling, make sure you can fill your products in a highly customized way. Tool-less format changes and filling stations with a variable number of filling heads increase the flexibility of your filling processes. Subsequent sealing is equally versatile, offering you a variety of methods such as gas burning or vacuum stopper insertion for tightly sealed containers. In-process control (IPC) further improves filling quality with constant checks of filling weight and stopper location.

barrier-systems

Barrier systems


Aseptic filling is all about product safety – and thus the separation of operators and pharmaceutical ingredients. Isolator technology helps to build this crucial barrier. With over 40 years of US-based and 25 years of Europe-based experience in the design and manufacture of barrier systems, Syntegon has established a comprehensive portfolio, including open RABS, closed RABS, containment and isolator systems. We focus on each component to make sure it seamlessly interacts with others: safe interfaces between filling machines, isolators and subsequent systems, e.g., freeze-dryers or capping machines are a top priority.

sterilization

Sterilization


The Syntegon company SBM (Schoeller-Bleckmann Medizintechnik) offers a vast portfolio of versatile sterilization solutions for an effective treatment of porous loads and liquids in open, semi-sealed or closed containers. The vacuum-steam, steam/air mixture and hot water shower processes support you in achieving reproducible equipment and terminal sterilization while optimizing your energy requirements.

inspection

Inspection


Like any pharmaceutical container, ampoules require thorough inspection to ensure patient safety. Our wide range of manual, semi and fully automated inspection machines inspects liquid and lyophilized pharmaceuticals for particles and container defects. Thanks to our long-standing inspection expertise, we offer state-of-the-art technologies for visual inspection and container closure integrity testing (CCIT), including high voltage leak detection (HVLD), static division (SD) and headspace analysis (HSA). Moreover, Syntegon provides fully integrated inline inspection solutions for several inspection tasks such as defects detection and stopper seat inspection.

pen-assembly

Pen assembly


Pens and cartridges are a winning team, provided they are assembled in an efficient, fully compliant way. Our modular assembly systems with scalable levels of automation make sure this is the case: they reliably support the production of standard 4-piece disposable pens and come in different designs according to your desired production rates. The rotary table version covers lower and medium outputs, while a linear transport system takes care of high-volume batches.

Expert Services
Expert Services

We support you throughout the entire machine life cycle, from spare parts management to digital line optimization. Service agreements are a key element of our portfolio structure. Together, we tailor our solutions to your individual needs. Our global network of experts supports you with maintenance planning, technical support, and modernizations, as well as operator training and end of life services. With our digital solutions, you gain control over your production processes and create transparency on product and machine data anytime, anywhere.

Maintenance & Support
Maintenance & Support

Spare Parts
Spare Parts

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Interested in these solutions meet your cartridge fill finish requirements?