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Tablet Compression

Tablet compression machines

Tablet compression with the Syntegon TPR tablet press series

Tablets are still the most popular Oral Solid Dosage (OSD) form. However, successful drug development is challenging. At Syntegon we develop tablet presses that are ideally suited for both pharmaceutical and nutrition and health products. Our TPR series consists of tablet compression machines featuring our renowned quality and an excellent price-performance ratio. The tablet presses answer the growing need for high efficiency, easy maintenance and operation – from R&D and pilot scale to high volume production. The same software is deployed throughout the TPR range. Its feeder and turret design also make the TPR series suited for MUPS (Multiple Unit Pellet System) tablets.

Key benefits

Integrated turret removal system
Accomplish complete product changeovers in less than one hour! Turret removal is even possible in only fifteen minutes without having to remove the upper and lower punches and their cam tracks.
Fast and easy cleaning
The TPR series offers a compact, hygienic design. It minimizes the production area allowing for fast and simple cleaning according to cGMP standards.
Powder feeding system
This modular system offers a two-paddle design with single or individually controlled paddle speeds. A third paddle can be added to assist smooth product flows.

Our tablet presses in action

FlexiTab XL for R&D

As a single punch machine for both R&D and galenics, the FlexiTab XL can produce a large range of tablet and oblong shapes (using up to three APIs in multiple layers) and analyzed them with the enhanced DAQ software.

TPR 500 for easy cleaning

The Syntegon TPR 500 is designed for ease of use, good accessibility, and reduced cleaning efforts. The two-level production zone ensures a consequent separation of the production and technical areas, giving you more time for production.

TPR 500 for medium and large batch production

The flexible Syntegon TPR 500 tablet press is the optimal solution for high productivity and quality combined with excellent usability. Reduced maintenance and cleaning efforts thanks to its hygienic design, as well as fast and easy changeovers give you more time for production.

TPR 700 for high volume production

The high speed, double-sided tablet press is capable of producing over one million tablets per hour with the latest technological advances in hardware and software. It is suitable for a wide range of products including pharmaceutical, confectionery (mints), nutraceutical (vitamins), medicated lozenges and non-pharmaceutical materials.

This single station tablet press with enhanced DAQ software is designed for R&D and galenics. As a single punch machine, the FlexiTab XL is ideal for early stage tablet development, clinical trial batches, the screening of powders or granules for subsequent product development, as well as the assessment of multi-layer drug dosing and characterization of powder properties. A large range of tablet and oblong shapes can be produced creating many layers, using up to three APIs. The formulator can manually or automatically sequence tablet production.

flexitab-XL-tablet-compression
flexitab-XL-tablet-compression
Tablet press FlexiTab XL
This single station tablet press with enhanced DAQ software is designed for R&D and galenics. As a single punch machine, the FlexiTab XL is ideal for early stage tablet development, clinical trial batches, the screening of powders or granules for subsequent product development, as well as the assessment of multi-layer drug dosing and characterization of powder properties. A large range of tablet and oblong shapes can be produced creating many layers, using up to three APIs. The formulator can manually or automatically sequence tablet production.
TPR-200-tablet-compression
Tablet press TPR 200
TPR 200 is a highly flexible and robust rotary tablet press for both R&D and small to medium size production batches. Thanks to a small footprint, this highly efficient tablet compression machine is economic and very compact. It is capable of producing approx. 230,000 tablets per hour, including bi-layer tablets with a set of conversion parts. The machine is easy to operate and to clean. Its range of functions is optimized to suit all tablet manufacturers who want to improve their Overall Equipment Effectiveness (OEE).
Tablet-press-TPR-200-Plus_Syntegon
Tablet press TPR 200 Plus

The TPR 200 Plus is a newly upgraded and very compact, medium output tablet press with great flexibility, improved handling and advanced operator protection. The ideal range of application is for R&D and clinical production activities, but it also copes with machine requirements for small and medium batch production environments. It is capable of producing approx. 230,000 tablets per hour, including bilayer tablets. Options include an OEB 3 protection cabin with glove port access and dry cleaning possibility.

syntegon-TPR-500-totale
Tablet press TPR 500
This highly flexible tablet press for medium and large production batches is the optimal solution for high productivity and quality combined with excellent usability. Reduced maintenance and cleaning efforts thanks to its hygienic design, as well as fast and easy changeovers enable you to better focus on production. The TPR 500 provides high output and yield capabilities at an excellent price-performance ratio. With a 56 station die table, the tablet press can produce up to 403,200 tablets per hour with standard tooling on a very small footprint. Our unique integrated die technology enables you to produce up to 16 mm tablets.
tablet-compression-machine
Tablet press TPR 700

The TPR 700 is the largest tablet press of the TPR series and capable of producing more than a million tablets per hour. This highly flexible machine is suited for a wide range of compressible products including pharmaceutical, confectionery (mints), nutraceutical (vitamins), medicated lozenges and non-pharmaceutical materials. The high speed, double-sided press features the latest technological advances in hardware and software. It can also produce bi-layer tablets with a set of conversion parts. Reduced width corner pillars provide excellent access to the production area. When using the exchangeable turret option, you can achieve an even wider range of tablet sizes and outputs.

Expert Services
Expert Services

We support you throughout the entire machine life cycle, from spare parts management to digital line optimization. Service agreements are a key element of our portfolio structure. Together, we tailor our solutions to your individual needs. Our global network of experts supports you with maintenance planning, technical support, and modernizations, as well as operator training and end of life services. With our digital solutions, you gain control over your production processes and create transparency on product and machine data anytime, anywhere.

Maintenance & Support
Maintenance & Support

Spare Parts
Spare Parts

Why choose Syntegon as your partner?

about-us

About us


Processing and packaging for a better life – this is what our employees work for every day. Looking back on a 160 years of experience, the portfolio of intelligent, innovative and reliable solutions help our customers in the global pharmaceutical and food industries to improve people‘s life.
With 1,100 service experts and a comprehensive service portfolio throughout the entire machine lifecycle from spare parts management to digital line optimization, Syntegon lays the foundation for smooth production processes for all customers.

years of experience 
patents and patent applications 
machines in the installed base 
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APD-feeder

Automated Process Development (APD) for tablet compression

Our new, automatically adjustable powder feeder and the APD software for tablet presses offer pharmaceutical manufacturers a complete package to determine the ideal process parameters for each product and easily transfer them to production machines. The APD tool, based on Design of Experiments (DoE), achieves faster and more precise results with much less product. The new powder feeding system is specifically tailored to the TPR 200.

Tablet compression downloads

FlexiTab XL flyer
FlexiTab XL flyer

The FlexiTab XL is a very versatile single punch tablet press, capable of producing tablets with single, two and even three layers.

TPR overview brochure
TPR overview brochure

Syntegon’s TPR tablet press series answers the growing need for high efficiency, easy maintenance and operation – from R&D and pilot scale to high volumes.

TPR 200 Plus
TPR 200 Plus

A highly flexible tablet press for both R&D and small to medium size production batches.

Pharma Solid overview brochure
Pharma Solid overview brochure

Our portfolio covers solid pharmaceutical processing and production: blending API with excipients, formulation preparation, granulation and particle coating, capsule filling, tableting and tablet coating.

R&D equipment brochure
R&D equipment brochure

Syntegon’s R&D machine portfolio covers all process steps: mixing, granulating, drying, tablet pressing and coating, pellet manufacturing, capsule filling and banding.

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