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    Robotic aseptic filling for gloveless Annex 1-compliant lines

    Reduce Grade A interventions with SynTiso, a gloveless, fully automated commercial fill & finish line designed to meet Annex 1 expectations.

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    SynTiso is engineered for zero-glove operations

    Annex 1 expectations, glove-based interventions and capacity targets increase challenges in robotic aseptic filling. As your strategic lifecycle partner, Syntegon applies SynTiso as a fully automated, gloveless commercial fill & finish line with 100% IPC designed to help meet Annex 1 expectations and re:imagine your aseptic production.

    Remove human touchpoints, align with Annex 1, scale with documented quality

    How to align with Annex 1 in Grade A?

    SynTiso cuts contamination routes with a gloveless, automated barrier.

    How to eliminate glove interventions at critical points?

    SynTiso automates aseptic set-up and handling to remove glove tasks.

    How to raise throughput with documented quality?

    SynTiso combines commercial speeds with 100% IPC at the core.

    SynTiso overview

    SynTiso frosted

    RTU infeed and biodecontamination

    Integrate bag and tub openers with short biodecontamination cycles to prepare RTU nests. 

    Gloveless isolator

    Support Grade A conditions with a gloveless isolator, integrated air management and fast biodecontamination cycles.

    Learn more

    Automated aseptic set-up, robotic handling and filling

    Run fully automated robotic handling for filling and closing to stabilize aseptic processing after an automated aseptic set-up.

    Frictionless transport

    Use frictionless transport that eliminates particle generation and glass-to-glass contact in the aseptic core.

    100% IPC and reject segregation

    Apply fully automatic 100% IPC at speed with a reject station for documented quality. 

    RTU format flexibility

    Process syringes, vials and cartridges on one platform with rapid size part only changeover.

    Learn more

    RackSter for faster batch changeover

    Bring sterilized parts to the SynTiso line with RackSter, our mobile sterilization and transfer system.

    Learn more
    SynTiso frosted

    RTU infeed and biodecontamination

    Integrate bag and tub openers with short biodecontamination cycles to prepare RTU nests. 

    SynTiso frosted

    Gloveless isolator

    Support Grade A conditions with a gloveless isolator, integrated air management and fast biodecontamination cycles.

    Learn more
    SynTiso frosted

    Automated aseptic set-up, robotic handling and filling

    Run fully automated robotic handling for filling and closing to stabilize aseptic processing after an automated aseptic set-up.

    SynTiso frosted

    Frictionless transport

    Use frictionless transport that eliminates particle generation and glass-to-glass contact in the aseptic core.

    SynTiso frosted

    100% IPC and reject segregation

    Apply fully automatic 100% IPC at speed with a reject station for documented quality. 

    SynTiso frosted

    RTU format flexibility

    Process syringes, vials and cartridges on one platform with rapid size part only changeover.

    Learn more
    SynTiso frosted

    RackSter for faster batch changeover

    Bring sterilized parts to the SynTiso line with RackSter, our mobile sterilization and transfer system.

    Learn more

    Explore the complete line

    RTU infeed and biodecontamination
    Gloveless isolator
    Automated aseptic set-up, robotic handling and filling
    Frictionless transport
    100% IPC and reject segregation
    RTU format flexibility
    RackSter for faster batch changeover

    Explore SynTiso for robotic aseptic filling

    26026-Syn-018

    Explore SynTiso for robotic aseptic filling

    Output performance
    Up to 600/min with fully automatic 100% IPC
    Special features

    Frictionless transport eliminating particles and glass-to-glass contact, with no wear of main transport element

    Format range
    RTU syringes, vials, cartridges
    Changeover
    Fast batch changeover, up to 50% faster vs traditional lines 
    Filling systems
    Peristaltic, piston, time-pressure; optional vacuum; single-use possible 
    Container types
    Vials 2R–50R; syringes 0.5–20 ml; cartridges 1–20 ml 
    Barrier technologies and line integration
    Gloveless isolator, integrated air management, fully integrated machine + isolator 

    Best if you want:

    • Gloveless, fully automated RTU line with 100% IPC up to 600/min
    • Up to 35% higher net unit output 
    Featured_Download_Teaser_SynTiso

    Annex 1-compliant commercial speed gloveless robotic aseptic filling with 100% IPC

    Learn how SynTiso answers Annex 1 challenges with a fully automated gloveless isolator.
    • Eliminate gloves in Grade A for superior contamination control
    • Reach up to 600/min with fully automated 100% in-process control
    • Recover availability with fast biodecontamination and up to 50% faster batch changeovers
    Download

    What sets SynTiso apart

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    Gloveless isolator with integrated air management

    Integrated air management protects Grade A conditions and simplifies line integration.
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    Fully automated robotic processing with 100% IPC

    Scale output without losing in-process control
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    RTU flexibility and faster changeovers

    Eliminate glass-to-glass contact and recover time between batches.
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    Highlight Topic

    Eliminate trade-offs in aseptic filling with SynTiso

    Get faster, cleaner, higher-yield production without compromise — SynTiso’s gloveless RTU line offers full automation, up to 600/min with 100% IPC, faster changeovers up to 50% and up to 35% more net units.

    Explore SynTiso

    Your strategic lifecycle partner for robotic aseptic filling

    service-life-cycle
    Ready for everything from start to routine

    From installation to optimization Syntegon supports you with structured service packages, training and specialists for safe, stable and resilient production across the lifecycle. 

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    service-life-uptime
    Secure availability – every day

    Fast spare parts, qualified support, and preventive maintenance help you avoid unplanned downtime, protect performance, and keep daily operations reliable.

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    service-future-ready
    Make your line fit for tomorrow

    Scalable retrofits and data solutions help you adapt to new demands, improve OEE, and keep your lines future-proof across changing requirements.

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    SynTiso knowledge hub

    Explore SynTiso – the next evolution.
    Explore SynTiso – the next evolution.

    Learn about our commercial speed gloveless isolator, automated aseptic set-up, and much more.

    Download
    Explore all RTU filling machines
    Explore all RTU filling machines

    Get an in-depth overview of advanced RTU filling solutions designed for syringes, vials, and cartridges.

    Download

    Frequently asked questions

    SynTiso applies fully automated robotic handling inside a gloveless isolator with integrated air management. The line employs 100% in process control while processing RTU syringes, vials and cartridges. The gloveless design eliminates manual touchpoints and aligns with Annex 1 expectations for minimized human intervention in Grade A.

    Measures include operating without gloves in Grade A, automated aseptic set up after biodecontamination, UDAF friendly first pass air and clear separation of aseptic and technical areas. Integrated air management supports stable conditions and contamination control across the line. These design choices align with Annex 1 expectations and support your contamination control strategy (CCS).

    SynTiso removes glove ports and uses robotic handling for set up and processing. Combined with integrated air management and first pass air, this reduces contamination routes in the aseptic core and supports Grade A conditions without routine glove interventions. 

    SynTiso achieves up to 600 containers per minute with fully automatic 100% in‑process control. Container‑level checks occur at line speed, and a reject station is available to segregate nonconforming units without disrupting flow. 

    SynTiso covers RTU syringes, vials and cartridges. Typical ranges include vials 2R–50R, syringes 0.5–20 ml and cartridges 1–20 ml, depending on configuration. This breadth lets teams handle common formats on one platform. 

    The transport system eliminates glass to glass contact, which supports gentle handling at speed and reduces mechanical wear. This frictionless transport strategy strengthens consistency in the aseptic core at commercial throughput.

    By eliminating glove ports and other design improvements, batch changeovers are up to 50% shorter versus traditional lines. Sites also see up to 35% higher net unit production when this approach is applied, supporting capacity goals.

    SynTiso pairs fully automatic 100% IPC with a reject station. Out‑of‑tolerance containers are removed immediately, which sustains documented quality and keeps the line running at planned speed. 

    Interested in SynTiso?

    Interested in SynTiso?

    Are you ready to revolutionize?

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