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Cartridge filling machines

Syntegon’s cartridge filling machines deliver reliable, high-precision performance across all output ranges ensuring accurate positioning, low-particle capping with patented technology, and consistent quality throughout the filling process.

Thanks to their modular and space-saving design, our machines integrate seamlessly into modern production lines. Syntegon supports you in optimizing efficiency, maintaining compliance and solving day-to-day production challenges.

Click the contact or download button below to learn how our cartridge filling machines can boost your production and add long-term value.

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We are Syntegon.
We are cartridge.

Cartridge processing is not just a production step – it’s a complex task that calls for support from a leading equipment manufacturer. If you are curious to find out why we are the undisputed number one in this field, explore our videos!

Automated cartridge filling line featuring integrated isolators, inspection systems, and downstream equipment for pharmaceutical production.

Solutions for complete cartridge lines with an output of up to 400 pcs./min.

cartridge-processing-solutions-for-complete-cartridge-lines-01

Solutions for complete cartridge lines with an output of up to 600 pcs./min.

When it comes to bioprocessing, the systems from Syntegon’s subsidiary Pharmatec flexibly support the production of small and large volume parenterals (SVP/LVP) and infusions (IV). The process solutions comprise modular set-ups of temperature-controlled stainless-steel tanks that can be assembled to meet customer-specific settings. The new, cost-efficient SVP Essential is a fully automated, ready-to-use system to produce simple parenterals such as analgesics, insulin, and generic drugs.

Benefits:

Adaptable to specific room conditions and floor plans
Continuous process monitoring for the highest possible safety
Suitable for toxic substances up to OEB5 in isolators
SVP Essential: less engineering effort, faster delivery times

Our formulation systems

cartridge-processing-formulation-systems

Before and after sealing, cartridges must be thoroughly cleaned – both inside and outside. This removes dust particles and other contaminants. Our compact cleaning systems for all performance ranges ensure hygienic and ergonomic processes with easy operation.

Benefits:

Cleaning of cartridges inside and outside
Highly precise siliconization inside, optionally also outside
Efficient use of cleaning water through recirculation

Our cleaning machines

cartridge-processing-cleaning

Our modular tunnel series uses dry heat to sterilize a wide range of containers safely and reliably by means of the unidirectional airflow principle. The proven temperature treatment makes sure the containers are sterilized in a fully definable and validatable way, which increases process safety and treatment quality. In addition, the HQL sterilization tunnels are highly flexibility and cost-effective thanks to their modular set-up and high level of automation.

Benefits:

Proven dry-heat sterilization (UDAF principle)
Gentle container handling via automated transport system
Automatic filter scan
Sustainable sterilization tunnel through energy savings by usage of heat recovery

Our sterilization & depyrogenation tunnels

cartridge-processing-depyrogenation

A time-pressure filling (TPF) system is typically used to fill cartridges, as this puts less mechanical stress on the drug product. We also offer a rolling diaphragm pump, a mass-flow filling pump and a rotary valve piston pump. If your product has specific requirements, a combi filling station could be the right choice.

Benefits of the typical used TPF filling system:

High dosing accuracy with small residual air bubble
No spilling of product and therefore maximum product yield
100% IPC station in case of combi filling lines
Customer centric design allow aseptic setup
Self-learning system

Benefits closing:

Continuous and secure placement of the combi caps on the filled cartridge
Stressless crimping through clipping out the cartridges with minimised particle generation

Our filling systems

Cartridge filling and closing process

Aseptic filling requires maximum product safety through strict separation of operators and pharmaceutical ingredients. Isolator technology creates this essential barrier. With over 40 years of US-based and 25 years of German-based expertise, Syntegon offers a complete portfolio: open/closed RABS, containment, and isolator systems.

We ensure all components work together seamlessly with safe interfaces between filling machines, isolators, and downstream systems like freeze-dryers or cappers.

Benefits:

Safe filling of aseptic and highly potent products
Advanced RABS, isolator, and barrier technology expertise
Isolator, bio-decontamination, and air-handling from one source

Our barrier systems

cartridge-processing-barrier-systems

Liquid medications in their containers and process equipment such as format parts have one thing in common: they require reliable sterilization to ensure maximum pharmaceutical safety and purity. Syntegon offers a wide range of different sterilization systems in various sizes for this purpose.

Benefits:

Wide range of processes
Hygienic design
Flexible recipe editor for customer-specific processes
Automatic inline filter sterilization

Our sterilizers

Syntegon_SBM_Sterilizer_ADV

Pharmaceutical containers require precise inspection for patient safety. Syntegon offers manual to fully automated solutions for detecting particles and defects in liquid and products in cartridges. Advanced visual inspection and CCIT technologies like HVLD, static division, and headspace analysis ensure reliable results.

Benefits:

Up to 24,000 units/h (AIM series)
Camera and light transmission inspection
Combining visual inspection and integrity testing with integrated leak testing
Modular, fast-delivery systems
Most precise detection of particles using our patented SD technology

Our inspection machines

cartridge-processing-inspection

Pens and cartridges are a winning team, provided they are assembled in an efficient, fully compliant way. Our modular assembly systems with scalable levels of automation make sure this is the case: they reliably support the production of standard 4-piece disposable pens and come in different designs according to your desired production rates. The rotary table version covers lower and medium outputs, while a linear transport system takes care of high-volume batches.

Benefits:

Good accessibility for easy format setting
Flexible modular design for future retrofits
Real-time machine monitoring via HMI

Our pen assembly & labeling machines

cartridge-processing-pen-assembly

cartridge-processing-different-types

Bulk cartridge filling

Bulk processing demands reliable, high-speed systems to ensure consistent quality. Syntegon’s flexible cartridge filling machines deliver high throughput with peak efficiency.

Our machines handle various product types and container sizes with fast, tool-less changeovers to reduce downtime. Fully automated, GMP-compliant systems ensure smooth, user-friendly operation.

Explore our full range of bulk processing solutions by clicking the button below.

Bulk processing

Syringe MLD Advanced_ABO_ATO

RTU cartridge filling

Syntegon offers a high-speed platform for RTU syringes, cartridges and vials, providing 100% IPC, flexible redosing and maximum product yield, as well as seamless integration into the pharmaceutical container processing value chain.

The MLD Advanced combines proven technologies with innovative solutions to provide the highest level of flexibility and efficiency.

RTU filling

cartridge-processing

Versynta – Our small batch portfolio

Versynta offers flexible small and micro batch filling at high throughput, handling up to 3,600 containers per hour like vials, syringes, or cartridges in RTU formats.

The fully automated Versynta microBatch integrates isolator and machine in one unit for aseptic, high-potency micro batches with minimal product loss and maximum sterility.

Click below to explore how Versynta supports your small batch production.

Versynta solutions

Our solutions have got you covered

Cartridge caps or cartridge stopper labeling

Cartridge caps or cartridge stopper labeling

Our tray loading system provides customisable outfeed trays and rejection options. Prior to traying the cartridges, several inline inspection possibilities are available, such as septum checking, checking the stopper position and identifying cap defects. Additionally, laser engraving can be included on either the stopper or the aluminium cartridge combi cap, enabling each cartridge to be identified by a unique or static number. A direct interface to a robotic handling system can also be established for further processing.

Glove testing

Glove testing

Thin elastomer gloves often constitute the sole barrier between isolated machines and operators. As such, they prove critical to many different barrier systems, and hence require regular and reproducible testing.

Tray loading

Tray loading

Gentle, safe, and fast – these are the top priorities when tray loading cartridges or vials. Syntegon’s loading solutions are designed for smooth transport and high output, processing up to 24,000 units per hour with reduced error rates.

Service Agreements

Service Agreements

Find out more about our Service Agreements here.

Digital Solutions

Digital Solutions

Find out more about Digital Solutions here.

Parts

Parts

Find out more about Parts here.

Maintenance

Maintenance

Find out more about Maintenance here.

Technical Support

Technical Support

Find out more about Technical Support here.

Modernizations

Modernizations

Find out more about Modernizations here.

Training

Training

Find out more about our Training here.

Expert Services

Expert Services

Find out more about our Expert Services here.

Cartridge processing downloads

Cartridge brochure

Cartridge brochure

Our solutions for processing cartridges

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