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    RTU vial filling for Annex 1 compliant aseptic processing

    Reduce Grade A interventions and changeover with gloveless isolators, robotics and 100% in‑process control across scalable vial platforms.

    Explore our RTU vial solutions

    Overall 5 Solutions
    Output performance
    Format range
    Special features
    Changeover
    Filling systems
    Container types
    Barrier technologies and line integration
    Benefits
    Versynta_microbatch
    Versynta microBatch
    Output performance
    Up to 450/h, nest 500/h, 1‑by‑1 vials 120/h
    Format range
    Vials 2R–50R, plus syringes 0.5–20 ml, cartridges 1-10 ml
    Special features
    Gloveless isolator, robotic workcell, 100% in‑process control
    Changeover
    Fast batch‑to‑batch changeovers
    Filling systems
    Peristaltic, rolling diaphragm
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    Gloveless isolator, integrated air management
    Benefits

    Best if you want:

    • Gloveless micro‑batch vial cell
    • Short biodecontamination and fast changeovers
    • Minimized product loss
    Brochure
    1080x720_VersyntaFFP
    Versynta FFP
    Output performance
    Up to 3,600/h
    Format range
    Vials 2R–50R, plus syringes 0.5–10 ml, cartridges 1–10 ml
    Special features
    100% in‑process control, isolator with integrated air management
    Changeover
    Size‑parts only, no module exchange
    Filling systems
    Peristaltic, piston, rolling diaphragm; vacuum filling and stoppering
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    Isolator with integrated air management
    Benefits

    Best if you want:

    • Size‑part only changeovers across containers
    • 100% in‑process control on all formats
    • Easy lyophilization integration
    Brochure
    1080x720_FXSCombi
    FXS Combi
    Output performance
    Small, Medium, High
    Format range
    Vials 2R–20R (25R, 30R optional), plus syringes 0.5–20 ml (50 optional), cartridges 3–10 ml
    Special features
    Fully automatic in‑process control (option), vacuum filling and vacuum stoppering
    Changeover
    Easy, quick format changes
    Filling systems
    Suited for Syntegon filling technologies, vacuum filling and vacuum stoppering
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    RABS, cRABS, isolator
    Benefits

    Best if you want:

    • One platform for vials, syringes, cartridges
    • Quick format changes with integrated capping
    • Flexible line concepts
    Brochure
    1080x720_MLDAdvanced
    MLD Advanced
    Output performance
    Up to 400/min
    Format range
    Vials 2R–30R, plus syringes 0.5–10 ml, cartridges 1–3 ml
    Special features
    100% in‑process control, modular conveyor, tub and nest handling
    Changeover
    Tool-free changeover
    Filling systems
    Multiple options including vacuum filling
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    Annex 1 compliant, flexible L or U layouts
    Benefits

    Best if you want:

    • Annex 1 compliant high‑speed vials
    • Add stations via modular conveyor (gassing, beading)
    • Flexible L or U layouts
    Brochure
    1080x1080_syntiso-1
    SynTiso
    Output performance
    Up to 600/min
    Format range
    Vials 2R–50R, plus syringes 0.5–20 ml, cartridges 1–20 ml
    Special features
    Gloveless in‑air isolator, frictionless transport, 100% in‑process control
    Changeover
    Automated aseptic set‑up functions
    Filling systems
    Peristaltic, piston, time‑pressure, vent‑tube or vacuum stoppering
    Container types
    Syringes, vials, cartridges
    Barrier technologies and line integration
    In‑air gloveless isolator, RackSter sterile parts transfer, connects lyophilization and inspection
    Benefits

    Best if you want:

    • In‑air gloveless isolator with frictionless transport
    • RackSter parts transfer and BFPC integration
    • OEE improvement >35%
    Brochure

    RTU vial standouts: gloveless assurance, fast changeovers, connected lines

    1080x1080_MBFmicroBatch

    Gloveless micro batch vials with 100% IPC

    Move clinical vials off high‑speed assets.
    1080x1080_isolator

    Size-part only changeovers in an integrated isolator

    Switch vial formats without opening the barrier.
    1080x1080_SynTiso008

    Frictionless transport in a gloveless in-air isolator

    Protect vials and verify each unit at speed.

    Explore related solutions for RTU vial filling

    1080x720_TrayLoading
    Tray loading
    1080x720_DSF0100
    Filling systems
    1080x720_VisualInspection2
    Visual inspection

    Your strategic lifecycle partner for RTU filling

    service-life-cycle
    Lifecycle and Annex 1 consulting for RTU lines

    Plan RTU projects with experts who know Annex 1 from URS to qualification. Service agreements, training and digital support keep performance stable across the lifecycle. 

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    service-life-uptime
    Secure availability – every day

    Fast spare parts, qualified support, and preventive maintenance help you avoid unplanned downtime, protect performance, and keep daily operations reliable.

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    service-future-ready
    Make your line fit for tomorrow

    Scalable retrofits and data solutions help you adapt to new demands, improve OEE, and keep your lines future-proof across changing requirements.

    Learn more
    Featured_Download_Teaser_RTU

    Plan your RTU filling portfolio with confidence

    See all Syntegon RTU filling options by output and container.

    • Match batch size to output
    • Compare RTU machines for each container
    • Check Annex 1 ready and IPC features
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    Assorted glass vials in various sizes with grey stoppers and green flip‑off caps for parenteral drugs.
    Case Study

    Stevanato Group boosts RTU vial safety with VHP decontamination

    Syntegon and Stevanato Group tested VHP to decontaminate RTU vials, cutting contamination risk and residual H2O2 while improving flexibility. 

    value-icon-innovative-technologies
    Innovative Technologies We enable market leadership.
    Read the full story
    1080x1080_syntiso-1
    Innovation Spotlight

    SynTiso gloveless RTU line for high speed filling

    See how SynTiso combines a gloveless isolator and up to 600 containers per minute for large RTU campaigns.

    Explore SynTiso

    Ready to use filling knowledge hub

    Explore all RTU filling machines
    Explore all RTU filling machines

    Get an in-depth overview of advanced RTU filling solutions designed for syringes, vials, and cartridges.

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    Explore SynTiso – the next evolution.
    Explore SynTiso – the next evolution.

    Learn more about SynTiso, the gloveless solution, that combines regulatory compliance with cutting-edge technology.

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    Small and micro batch whitepaper
    Small and micro batch whitepaper

    Learn how small and micro batches are changing pharmaceutical processes.

    Download

    Frequently asked questions

    RTU vials arrive pre-sterilized and nested, which reduces in-house prep and lets teams focus on filling and closing. Barrier concepts and 100% in-process control are available on several platforms to cut Grade A interventions and verify every unit.

    Portfolio coverage includes vials 2R–50R on Versynta microBatch, Versynta FFP, and SynTiso, and 2R–30R on MLD Advanced. Exact ranges depend on the selected platform and options.

    • Versynta microBatch: up to 450/h; one‑by‑one up to 120/h
    • Versynta FFP: up to 3,600/h
    • MLD Advanced: up to 400/min with 100% IPC
    • SynTiso: up to 600/min with 100% IPC

    They use barrier technologies and automation to reduce interventions. SynTiso is Annex 1‑compliant with an in‑air gloveless isolator and 100% IPC. FFP integrates an isolator with air management, and microBatch runs in a gloveless isolator cell.

    Yes. Versynta microBatch, Versynta FFP, MLD Advanced, and SynTiso process syringes, vials, and cartridges within defined ranges. FXS Combi also runs all three container types on one machine with quick format changes.

    Options include peristaltic, piston, rolling diaphragm, and time‑pressure filling on SynTiso, plus vent‑tube or vacuum stoppering. MLD Advanced offers multiple filling options including vacuum filling, with vent‑tube and vacuum stoppering available. FXS platforms offer vacuum filling and vacuum stoppering as options. Availability depends on configuration.

    SynTiso connects upstream and downstream processes such as lyophilization and inspection and automates sterile parts transfer via RackSter. Versynta FFP offers easy freeze‑dryer integration within its isolator concept.

    Interested in filling RTU cartridges, syringes & vials?

    Interested in filling RTU cartridges, syringes & vials?

    Talk to a Syntegon expert to learn more about RTU filling solutions.

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