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    Food Pharma

    Capping & Coding

    | 3 min read

    Any pharmaceutical vial or infusion bottle is only as good as its closure. Our capping and sealing solutions keep your medications safe and your line flexible and efficient – while our coding machines ensure reliable traceability.  

    overseal-capping-machine-VRK-1

    Rising requirements and regulations are increasing pressure on the food industry. With modern VFFS technology, Syntegon enables manufacturers to secure quality, speed and compliance at the same time without compromising efficiency or sustainability.

    Key takeaways

    • Product integrity and easy validation thanks to precise, reproducible capping and sealing processes
    • Low-particle processes and hygienic design support Annex 1 compliance and minimize contamination risks
    • Integrated coding and verification enable full traceability and regulatory compliance
    • Multiple inspection systems maximize product yield
    • Scalable solutions and lifecycle services ensure reliable, future-ready fill-finish operations

    It is the crucial final step in pharmaceutical fill-finish processes: Vials and infusion bottles must be securely capped and sealed to maintain sterility and ensure the quality of sensitive products throughout the supply chain. Pharmaceutical and biotech companies face the challenge of combining precise, reproducible processes with low-particle operation under strict regulatory requirements such as Annex 1.

    At the same time, increasing product diversity and batch variability require flexible equipment that can handle different container and cap formats without compromising efficiency. Syntegon’s portfolio of capping, sealing, and coding machines supports pharmaceutical and biotech companies in addressing these demands.

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    Capping and sealing precision for product integrity at any output

    Our ARF-B and VRK overseal capping machines deliver the reproducible precision, validatable compliance, and flexible efficiency required in modern fill-finish environments.

    The ARF-B caps and seals up to 8,400 containers per hour and is designed for maximum product and operator safety: With its low-particle crimping method and transport system that releases containers during the crimping process, it ensures ideal isolator use and full Annex 1 compliance.

    The VRK is perfectly suited to larger operations output requirements of up to 36,000 containers per hour. Despite its speed, it ensures gentle container handling to maintain product integrity. Its dedicated crimping discs with adjustable parameters for different stopper and cap combinations combined with fast format changeovers through servo-driven automatic adjustment allow for efficient handling of multiple container formats. An easy-to-clean, hygienic design and optional integration into isolators or RABS minimize contamination risk.

    Both machines feature integrated inspection systems for product safety and increased efficiency, e.g., via high-speed cap roundness verification that avoids any uncapped vials. Easily reproducible settings further contribute to reliable processes and easy validation.

    Capping and sealing – your benefits at a glance

    • Precise and reproducible capping and sealing for easy-to-validate, consistent product integrity
    • Easy isolator and RABS integration and low-particle process minimize contamination risks
    • High flexibility for container and cap formats and output range

    coding-and-verification-machine-KIV

    In-line coding ensures full traceability

    In addition to a secure closure, reliable identification is essential to protect against counterfeiting and meet regulatory requirements.

    Our in-line KIV series applies – either with thermo inkjet printer or laser printer – and verifies individual codes on each container to ensure their traceability across the entire supply chain. The KIV systems mark up to 36,000 containers per hour, combining high quality and with consistent performance.

    They can be seamlessly integrated into capping processes or used as standalone solutions, offering flexibility for different production setups.

    Coding and verification – your benefits at a glance

    • Reliable marking and verification for full traceability

    • Enhanced compliance and counterfeiting protection

    • Flexible integration into new or existing production lines

    We are your lifecycle partner for secure closure and traceability

    Whether it is vials or infusion bottles you need to cap, seal, and code – we are your partner for solutions that deliver precise results, maintain high hygiene standards, enhance the compliance of your processes, and offer the flexibility to adapt to different production needs. Syntegon supports you with seamless solutions and lifecycle services to ensure your fill-finish operations are safe, efficient, and future-ready. 

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