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pure-media
Pure media & formulation systems

Our portfolio includes both distillation and cold membrane processes for WFI, as well as thermal generation solutions for WFI and pure steam. Our formulation systems, in turn, support you in producing the actual solutions.

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cleaning-&-depyrogenation
Cleaning & depyrogenation

Syntegon offers internal and external cleaning machines for vials and other containers. Once the vials have been pre-cleaned with Water for Injection (WFI), our HQL tunnel ensures safe and reliable sterilization and depyrogenation with dry heat.

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filling-and-closing
Filling & closing

Every filling system makes sure you can fill your products in a highly customized way. Tool-less format changes and filling stations with a variable number of filling heads increase the flexibility of your filling processes. Subsequent sealing offers you a variety of methods such as pick and place or continuous stoppering.

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capping
Capping

Continuous capping with high speeds completes the safe and reliable closing process. 100 % in-process control (IPC) check weighing and inline inspection systems for empty vials, stopper position or crimp quality further increase product quality.

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external-cleaning
External cleaning

Following filling and capping, the vials can be transferred to our RAN external cleaning machine, which makes sure that no particles adhere to the outer sides of the vials.

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barrier-systems
Barrier systems

Syntegon has established a comprehensive portfolio, including open RABS, closed RABS, containment and isolator systems.

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freeze-drying
Freeze drying

The GMP-compliant freeze dryer is suited to produce small and large batches, is processing a wide array of container sizes and formats and also pays off regarding energy efficiency.

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sterilization
Sterilization

Versatile sterilization solutions for an effective treatment of porous loads and liquids in open, semi-sealed or closed containers.

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inspection
Inspection

State-of-the-art technologies for visual inspection and container closure integrity testing (CCIT), including high voltage leak detection (HVLD), static division (SD) and headspace analysis (HSA).

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The right match
for your needs

These solutions meet your fill-finish requirements for liquid vials

Our customers process some of the most valuable and urgently needed pharmaceutical liquids, for example the new Covid-19 vaccines, oncology preparations or other biopharmaceutical drugs on our lines 24/7. Are you also looking for a reliable, safe, and efficient solution for your liquid vials? From stand-alone machines to entire lines – we are your experienced partner!

pure-media

Pure media & formulation systems


Purified media are a prerequisite for processing and producing liquid pharmaceuticals. Our portfolio includes both distillation and cold membrane processes for WFI, as well as thermal generation solutions for WFI and pure steam. Of course, we also offer you a well-designed system concept for the storage and distribution of PW and WFI. Our formulation systems, in turn, support you in producing the actual solutions. From preparation and filtration to centrifugation and chromatography – ask our experts and they will be sure to propose the right solution for your products.

depyrogeneration

Cleaning & depyrogenation


Sterility matters across the entire aseptic process – before, during and after sterile filling. Syntegon offers internal and external cleaning machines for vials and other containers. Once the vials have been pre-cleaned with Water for Injection (WFI), our HQL tunnel ensures safe and reliable sterilization and depyrogenation with dry heat. Following filling and capping, the vials can be transferred to our RAN external cleaning machine, which makes sure that no particles adhere to the outer sides of the vials; an important factor in protecting operators and healthcare workers

filling

Filling & closing


Our vial filling systems combine flexibility and precision: a wide range of technologies, including valve piston and peristaltic pump, mass-flow, rolling diaphragm pump, time-pressure filling – or a combination of all within our combi filling station. Every filling system makes sure you can fill your products in a highly customized way. Tool-less format changes and filling stations with a variable number of filling heads increase the flexibility of your filling processes. Subsequent sealing offers you a variety of methods such as pick and place or continuous stoppering – without the use of vacuum. Continuous capping with high speeds completes the safe and reliable closing process. Quality will be increased with constant checks of filling weight by 100% check weighing systems (IPC) and inline inspection systems as empty vial inspection, stopper position control, crimp quality, cap roundness, print check - or whatever is required to control. Fully integrated into Syntegon machine control.

barrier

Barrier systems


Aseptic filling is all about product safety – and thus the separation of operators and pharmaceutical ingredients. Isolator technology helps to build this crucial barrier. Syntegon has established a comprehensive portfolio, including open RABS, closed RABS, containment and isolator systems. All solutions are tailored to customer requirements, from machine design and development to on-site installation and validation.

freeze

Freeze drying


The freeze dryer developed by the Syntegon subsidiary SBM is a true allrounder. It combines modularity and a flexibile design, making optimum use of the available space while processing a wide array of container sizes and formats. As such, the GMP-compliant freeze dryer is not only suited to produce small and large batches. It also pays off regarding energy efficiency: especially light product shelves reduce the amount of material that needs cooling and heating. These intelligent solutions help to significantly shorten secondary processes and contribute to the freeze dryer’s energy-saving potential.

sterilization-01

Sterilization


SBM (Schoeller-Bleckmann Medizintechnik) offers a vast portfolio of versatile sterilization solutions for an effective treatment of porous loads and liquids in open, semi-sealed or closed containers. The vacuum-steam, steam/air mixture and hot water shower processes support you in achieving reproducible equipment and terminal sterilization while optimizing your energy requirements

inspection-01

Inspection


Inspection is a key quality safeguard for pharmaceuticals and contributes significantly to patient safety. It can also help to improve the entire production process. Our wide range of manual, semi and fully automated inspection machines inspects liquid and lyophilized pharmaceuticals for particles and container defects. Thanks to our long-standing inspection expertise, we offer state-of-the-art technologies for visual inspection and container closure integrity testing (CCIT), including high voltage leak detection (HVLD), static division (SD) and headspace analysis (HSA). During the filling process, inline inspection systems for empty vials, stopper position or crimp quality further increase product quality.

Expert Services
Expert Services

We support you throughout the entire machine life cycle, from spare parts management to digital line optimization. Service agreements are a key element of our portfolio structure. Together, we tailor our solutions to your individual needs. Our global network of experts supports you with maintenance planning, technical support, and modernizations, as well as operator training and end of life services. With our digital solutions, you gain control over your production processes and create transparency on product and machine data anytime, anywhere.

Maintenance & Support
Maintenance & Support

Spare Parts
Spare Parts

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Interested in these solutions meet your fill-finish requirements for liquid vials?