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Visual inspection machines

From manual inspection to intelligent automation – find the ideal visual inspection solution for you.

Visual inspection is a critical requirement for parenterals, mandated by regulatory authorities all over the world to ensure the highest product quality and patient safety. Syntegon is the strategic partner for both CDMOs or fully integrated pharmaceutical companies who want to achieve the most efficient inspection results.

Whether you require manual, semi-automated or fully automated visual inspection equipment, or integrated solutions with CCIT or Artificial Intelligence, Syntegon is your point of contact. With decades of experience and our Japanese heritage with a focus on quality, we are constantly developing innovative solutions to make your inspection processes ever more effective.

Let’s get in touch to discuss your visual inspection requirements.

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Solving your visual inspection challenges

The highest safety requirements

Product and patient safety, as well as strict regulatory compliance are paramount in the pharmaceutical industry – and especially in end-of-line inspection. We have the equipment and the experience to make your products meet all safety requirements.

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Achieving maximum OEE and efficiency

Every drop of your drugs should reach the patients efficiently. Hence, our visual inspection machines are designed to achieve high detection rates at maximum OEE, while reducing false reject rates to a minimum.

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Flexibility and seamless integration

Different products and container types call for highly flexible solutions. Our visual inspection machines make your life easier by accommodating the most products and containers, and integrating seamlessly into your production lines.

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The advantage for your line

Safety for products and patients

Our visual inspection machines with optionally integrated CCIT support you to be compliant with regulations such as EU GMP Annex 1. They deliver safety inspected products for patients around the world.

Highly efficient inspection processes

With many machines running reliably in the field for more than 30 years, our visual inspection solutions stand for a low total cost of ownership and minimum false reject rates.

Count on long-standing expertise

With more than 50 years of inspection expertise and backed by our Japanese heritage from Eisai Machinery, we are your trusted partner for safe, efficient, and seamless visual inspection solutions.

Cracks and leaks pose a threat as as critical as as foreign particles. With integrated CCIT, you can ensure 100% leak detection with either integrated HVLD or HSA of every container – safeguarding product quality and complying with regulatory standards.

What it means for you:

Added layer of safety: detect micro-leaks invisible to cameras.
Highly reliable: non-destructive high-speed testing with high accuracy.
Small footprint: save space by integrating CCIT and visual inspection in one machine.

Are you filling freeze-dried products or liquids under nitrogen in a protective atmosphere? Then you know how critical oxygen levels are. Head-space analysis (HSA) measures non-conform oxygen concentration or water vapor pressure inside the container to detect leaks.

What it means for you:

Detect all leaks: HSA detects both temporary and permanent leaks.
Highly reliable: non-destructive high-speed testing with high accuracy.
Small footprint: save space by integrating CCIT and visual inspection in one machine.

Finding the right vision recipe — whether for new products and formats or refining existing ones — takes time. Balancing high detection rates with accurate defect recognition is key to achieving optimal performance on your visual inspection machine.

What it means for you:

All-in-one recipe creation support: use captured images or generate them offline with a compact unit that replicates a full AIM inspection setup, including vision software, camera, lighting, vision system, and spinning speeds.
Increased efficiency: improve detection rates and reduce false reject rates with optimized recipes.
Operator training: qualify staff offline in accordance with GxP requirements.

Our AIM DIRect handles nested syringes efficiently and safely. It eliminates the risks of breakage and unplanned downtime by seamlessly de-nesting and re-nesting syringes with precision and care – at full production speeds.

What it means for you:

Maximum efficiency: nests are gripped, extracted, and returned automatically.
Prevent defects: low vibration transport without glass contact avoids unwanted scratches or breakage that can interfere with inspection systems
Speed up production: the AIM DIRect can handle up to 600 syringes per minute.

Freeze-dried products

Lyophilized drugs like antibiotics or vaccines are often difficult to inspect, as their variable characteristics might be mistaken for defects. High-quality cameras and illumination setups make even the smallest particles visible and can even be combined with deep learning models.

Milky products

Particles and defects in milky products such as propofol are best detected using camera inspection. We offer different camera technologies, spinning systems, and special illumination setups to maximize detection and reduce false reject rates.

Water-like products

Detect even the smallest particles inside containers filled with water-like products such as vaccines or GLP-1s with our patented SD technology. We also offer different illumination systems such as transmitted or reflected light to make particles visible optimally.

Suspensions

Particles in suspensions such as insulins and vaccines are more difficult to inspect than in clear liquids. We use additional spinning and specialized lighting technologies to move particles towards the container walls and make unwanted particles more visible.

Bubble-prone products

Protein-based drugs often form bubbles that resemble defects. Our patented Bubble Masking tool, reliably distinguish harmless bubbles from real defects, ensuring accurate inspection and reducing false reject rates.

Patented SD technology

Our patented Static Division (SD) technology uses light and sensors to detect moving particles with precision. It is known for its simple setup and quick validation process. The system inspects only the interior of the container, ensuring focused and reliable analysis.

Camera inspection

Camera inspection technologies are designed to detect moving particles and cosmetic defects. While area cameras take several complete high-res images, line scan cameras capture images line by line and stitch them together into a full 360° image.

Patented bubble masking

Our bubble masking algorithms identify bubbles based on their distinct shape and distinguish them from real defects. This significantly reduces false reject rates and lowers costs from unnecessary manual re-inspections.

Downloads

Syntegon Inspection Solutions Brochure

Manual, semi- and fully automated inspection machines, Deep Learning, leak testing & service packages to ensure safe drug delivery

HVLD Guide: 100 % Container Integrity

Discover how integrating HVLD with automated visual inspection secures container integrity, meets Annex 1 and protects patients.

Interested in Visual inspection machines and solutions?

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Answers to your visual inspection questions

Do you have questions about visual inspection machines and solutions? We have compiled answers to the most common questions to help you make an informed decision. If you need more details, feel free to explore our solutions, or contact our experts for personal support.

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Our visual inspection solutions can detect a wide range of defects: from particulates from various sources such as rubber, metal, or glass to cosmetic flaws like scratches, cracks, or crimp defects through to issues like incorrect fill levels or leaks that may compromise container integrity – even when they are not visible to the naked eye. This ensures the highest standards of product safety and quality.

Automated visual inspection solutions dramatically increase efficiency, enabling pharmaceutical companies to scale up production and bring more medicines to a broader market – faster and more cost-effectively. Unlike manual inspection, which can be influenced by human variability and environmental factors like fatigue or lighting, automated systems deliver consistent, objective, and highly reliable results. This not only ensures product quality and patient safety but also supports global access to critical treatments by accelerating throughput without compromising accuracy.

Our inspection systems offer full flexibility. They can be directly connected to the filling line for immediate inspection – whether in bulk or in ready-to-use nests – or operated as stand-alone units, if you prefer to inspect containers later, e.g. after storage or just before they reach patients. Adding container closure integrity testing (CCIT) is also straightforward: technologies like high-voltage leak detection (HVLD) or head-space analysis (HAS) can be seamlessly integrated into the visual inspection machine, eliminating the need for separate equipment and making the manufacturing process even more streamlined.

One of the core principles of our machines is helping you stay compliant. All our automated systems meet global GMP standards, ensuring consistent, validated performance throughout the inspection process. For manual inspection, we adhere to pharmacopeial guidelines (e.g., USP, EP, JP), which define requirements for lighting, background, and inspector qualification – ensuring reliable and repeatable results under controlled conditions.

Implementing our automated visual inspection solutions typically results in significant cost savings by reducing product recalls, minimizing waste, and improving overall production efficiency. The ROI depends on several factors, including machine reliability, detection and false reject rates, operating time, maintenance efforts, and the initial investment cost. Our systems are designed for fast deployment, high uptime, and minimal false rejects – key factors that help you achieve a quick and measurable ROI.

Syntegon provides comprehensive after-sales support and training to ensure smooth operations after installation. Our dedicated service teams offer maintenance, troubleshooting, and upgrades, helping you minimize downtime and extend the lifespan of your equipment. Additionally, we offer operator training sessions tailored to your team’s needs, so they are well-prepared to manage the equipment efficiently.

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Visual inspection machines

Solving your visual inspection challenges

The highest safety requirements

Achieving maximum OEE and efficiency

Flexibility and seamless integration

Find your ideal visual inspection machines and solutions

Select your Technology

Manual (up to 4 units per minute)

Automated (up to 400 units per minute)

Select your Technology

Select your Technology

Select your Technology

Select your Technology

Select your Technology

Manual (up to 4 units per minute)

Automated (up to 400 units per minute)

Select your Technology

Manual (up to 4 units per minute)

Automated (up to 600 units per minute)

Manual (up to 4 units per minute)

The advantage for your line

Safety for products and patients

Highly efficient inspection processes

Count on long-standing expertise

Visual Inspection products

Freeze-dried products

Milky products

Water-like products

Suspensions

Bubble-prone products

Overview of our visual inspection technologies

Patented SD technology

Camera inspection

Patented bubble masking

Downloads

Syntegon Inspection Solutions Brochure

HVLD Guide: 100 % Container Integrity

Interested in Visual inspection machines and solutions?

Local Agent

Answers to your visual inspection questions

What types of defects can your visual inspection machines detect?

What are the primary benefits of automated visual inspection solutions?

How do your inspection solutions integrate with our existing manufacturing processes?

What regulatory standards do your automated visual inspection systems comply with?

What is the return on investment (ROI) of implementing automated visual inspection?

What level of after-sales support and training can I expect?

Our customers are also interested in