Pharmaceutical Filling Machines | Precise & Efficient

Various sterile pharmaceutical containers including vials, cartridges, ampoules, and syringes, compatible with pharmaceutical filling machine applications in aseptic production.

In sterile pharmaceutical production, precision and reliability are critical. Whether you're filling high-potency drugs or sensitive biologics, Syntegon’s advanced pharmaceutical filling machines are built to meet the toughest industry demands, helping you stay compliant, efficient and competitive.

We combine proven technology with smart automation and digital tools to support your production goals. From aseptic accuracy to full process transparency, our solutions are designed to solve real challenges and deliver lasting value.

Click the contact or download button below to speak with our experts or access our brochure and see how Syntegon’s filling systems can elevate your operations.

Connect with an expert Download our brochure

Key benefits

Unmatched variety

We offer the widest range of sterile filling technologies for different applications, including suspensions, viscous liquids, and aqueous solutions.

High dosing accuracy

Our state-of-the-art filling systems comprise sensors to measure volume flows and precisely dose filling quantities.

Thorough testing

Each technology undergoes rigorous trials with original products or placebos at our lab to ensure full functionality.

Filling biotechnologically produced active ingredients places special demands on pump technology.

Our user-friendly peristaltic pump ensures gentle operation and precise dosing of cost-intensive products. As it does not require any format parts except for the hoses, the system can be operated with one hand using clip connectors. Thanks to these versatile features, the peristaltic pump is ideal for the use in barrier systems according to the EU GMP Annex 1 guidelines.

What’s more, this pump type is particularly suited for single-use applications.

Benefits:

Ideal for shear-sensitive products
Easy handling
No format parts

Peristaltic pump system with multiple filling nozzles and single-use tubing, integrated into a pharmaceutical filling machine for precise and sterile liquid dosing.

The rotary valve piston pump is extremely flexible and can be used for a wide range of applications. Its volumetric operating principle ensures high dosing accuracy for both aqueous and highly viscous liquids.

The ceramic version of the pump can also be used to fill hot and abrasive products.

The optional Smart Pump variant ensures maximum process reliability and precision while opening up new possibilities for predictive maintenance.

Benefits:

Wide range of applications
High flexibility
Available as stainless steel and ceramic versions

Rotary valve piston pump system with multiple filling stations and green tubing, integrated into a pharmaceutical filling machine for high-precision liquid filling.

The rolling diaphragm pump combines the advantages of the peristaltic and rotary valve piston pumps. It offers gentle product handling thanks to the absence of shear contours combined with the dosing precision of a volumetric filling system.

The pump’s flexible diaphragm gently conveys the product through a piston and the pump body.

The technology is available both as a CIP/SIP and a single-use version to meet very demanding production requirements.

Benefits:

Innovative product conveying concept
CIP/SIP, stainless steel, or single-use version
Gentle product handling, perfectly suited for biopharmaceuticals

Rolling diaphragm pump system with stainless steel components and precision dosing heads, integrated into a pharmaceutical filling machine for aseptic liquid filling applications.

The increasing demand for space-saving machines with barrier systems requires ever more compact filling systems. This is especially true for the high-performance range and the use of a large number of filling stations. Thanks to its space-saving design, the time-pressure filling system ideally meets these requirements.

In connection with a minimum of moving mechanical parts, an intelligent algorithm enables gentle and precise filling.

Benefits:

Highly compact
Optimal accessibility
Easy format changeover

Time-pressure filling system with multiple nozzles and green tubing, integrated into a pharmaceutical filling machine for high-speed, precise dosing in aseptic environments.

A mass-flow sensor operating according to the Coriolis principle in each filling section ensures 100% in-process control and precise filling operations.

This sophisticated sensor technology further enables the system to manage demanding tasks such as hot and cold filling.

Benefits:

100% in-process control (IPC)
Particularly suited for cold or hot products
Preferred system for X-ray products

Mass flow filling system with precision sensors and stainless steel piping, integrated into a pharmaceutical filling machine for accurate, real-time liquid dosing.

Our innovative Smart Pump provides full transparency. State-of-the-art RFID technology transmits pump-specific parameters such as cleaning status, serial number, and correction values to the filling machine via a reading device. This allows operators to read the visualized data on the machine’s HMI conveniently and reliably.

Benefits:

Process reliability
Effectiveness
Validation and traceability

Smart pump module with real-time sensor data for position, cleaning status, and dosing correction, integrated into a pharmaceutical filling machine for intelligent liquid handling.

Filling different products with specific properties often requires more than one filling system. Our patented combi filling stations can combine several filling systems on one machine, allowing you to flexibly adapt your production line at any time.

Benefits:

Up to four filling systems on one filling station
Patented design
Suitable for stainless steel and single-use systems

Combi-filling system integrated into a pharmaceutical filling machine, equipped with multiple nozzles and flexible tubing for handling different container types in aseptic production.

Syntegon’s single-use technology, known as PreVAS in the U.S., transforms sterile liquid pharmaceutical filling. PreVAS stands for pre-validated, pre-assembled and pre-sterilized, a fully customizable, ready-to-use fluid path with extensive regulatory validations. Delivered gamma-sterilized and fully assembled, it integrates easily with most Syntegon filling machines and supports both peristaltic and rolling diaphragm pumps. PreVAS enables fast batch changeovers, reduces time to market, and offers high production flexibility.

Benefits:

No cleaning or sterilization of reusable equipment
Prevents cross-contamination between batches
Minimizes operator exposure to potent products

Single-use pharmaceutical filling machine setup with flexible tubing and stainless steel components, designed for aseptic drug filling in sterile production environments.

Interested?

Get in touch with us.

Service Agreements

Find out more about our Service Agreements here.

Learn more

Digital Solutions

Find out more about Digital Solutions here.

Learn more

Parts

Find out more about Parts here.

Learn more

Maintenance

Find out more about Maintenance here.

Learn more

Technical Support

Find out more about Technical Support here.

Learn more

Modernizations

Find out more about Modernizations here.

Learn more

Training

Find out more about our Training here.

Learn more

Expert Services

Find out more about our Expert Services here.

Learn more

Pharmaceutical filling machine with single-use tubing and multiple filling heads, designed for aseptic liquid dosing in sterile cleanroom environments.

Patented innovation: Our in-house technologies like the rolling diaphragm pump and combi station offer precise, gentle filling and flexibility for a wide range of containers and products.
These solutions are designed to ensure product integrity, reduce waste, and support high-quality pharmaceutical production.

Leading portfolio: With the broadest range of filling systems on the market, Syntegon enables full customization to meet your specific production needs, from small batches to high-speed lines. Our modular systems allow for easy upgrades and seamless integration into existing production environments.

Digital integration: Built-in digital solutions provide real-time process monitoring and full data transparency, supporting compliance, efficiency, and control throughout your operations.

years of experience

patents and patent applications

solutions installed worldwide

locations

Downloads

Smart Pump

The innovative filling solution

Filling Systems Applications

Interested in pharmaceutical filling machines?

Country/Region

Read our latest pharma news

11.09.2025

CPHI Frankfurt: “At the heart of Pharma”

From October 28 to 30, manufacturers and suppliers from the pharmaceutical industry will once again gather for a special highlight: CPHI is dedicated to the latest trends and technologies.

Supporting self-medication with cutting-edge assembly solutions

Pens and auto-injectors are highly sought-after administration solutions for injectables. From...

Sustainability in pharma with hot water sterilizers from Syntegon

Discover how Syntegon partners with pharmaceutical manufacturers to balance sustainability,...

Energy efficiency in pure steam generation

The pharmaceutical industry needs to produce faster and more sustainably. Learn how innovative pure...

Syntegon Pharma at Pack Expo 2025: from lab to global scale

Syntegon Pack Expo Las Vegas, September 29 - October 1. Discover our RTU processing solutions for...

More Syntegon News

Pharmaceutical filling machine

Key benefits

Unmatched variety

High dosing accuracy

Thorough testing

Our filling systems and their functions

Interested?

Service Agreements

Digital Solutions

Parts

Maintenance

Technical Support

Modernizations

Training

Expert Services

Why choose our pharmaceutical filling machine?

Downloads

Smart Pump

Filling Systems Applications

Interested in pharmaceutical filling machines?

Local Agent

Read our latest pharma news