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    Person in cleanroom gown and gloves holding a nest of ready to use containers with green caps up to the light for visual inspection.

    Ready to use filling Annex 1 compliant aseptic lines

    Keep ready to use (RTU) filling under control while you scale from micro batches to high-speed lines and reduce Grade A interventions.

    Talk to RTU filling experts See RTU downloads

    De-risk ready to use filling

    RTU filling must deliver reliable aseptic product, compliant with Annex 1 expectations, no matter the output. Each format change or upgrade touches your contamination control strategy and can add lead time, cost and Grade A intervention risk.

    Syntegon combines RTU filling equipment, barrier design and automation with lifecycle support from URS to modernization so you can expand capacity with less regulatory risk.

    Turn RTU filling challenges into impact

    How to cut contamination risk?

    Use gloveless isolator-based RTU filling equipment.

    How to scale RTU fill/finish?

    Combine modular RTU filling platforms for micro, small and high output.

    How to modernize RTU filling equipment?

    Use Syntegon services to upgrade RTU filling equipment for Annex 1.

    Explore our end-to-end, Annex 1 compliant RTU filling solution

    Syringe MLD Advanced_ABO_ATO

    No touch transfer into the cleanroom

    Use an automated bag opener to move RTU bags into the clean area without manual contact and fewer particle risks. 

    Automated RTU tub opening

    Open RTU tubs in a controlled process so nests enter the aseptic core aligned, intact and with minimal handling.

    RTU filling line with isolator

    Fill syringes, vials and cartridges in an isolator that cuts Grade A entries and enables 100% IPC.

    Isolator technology for RTU aseptic cores

    Use integrated isolators with fast biodecontamination and ergonomic access, designed to help you meet Annex 1 expectations.
    See isolator solutions
    Syringe MLD Advanced_ABO_ATO

    No touch transfer into the cleanroom

    Use an automated bag opener to move RTU bags into the clean area without manual contact and fewer particle risks. 
    Syringe MLD Advanced_ABO_ATO

    Automated RTU tub opening

    Open RTU tubs in a controlled process so nests enter the aseptic core aligned, intact and with minimal handling.
    Syringe MLD Advanced_ABO_ATO

    RTU filling line with isolator

    Fill syringes, vials and cartridges in an isolator that cuts Grade A entries and enables 100% IPC.

    Syringe MLD Advanced_ABO_ATO

    Isolator technology for RTU aseptic cores

    Use integrated isolators with fast biodecontamination and ergonomic access, designed to help you meet Annex 1 expectations.
    See isolator solutions

    Explore the complete line

    No touch transfer
    Tub opener
    RTU filling line
    Isolator technology

    Solution Finder

    Find the right ready to use filling solution

    Assorted glass vials in various sizes with grey stoppers and green flip‑off caps for parenteral drugs.
    RTU vial filling
    Group of prefilled glass syringes in different sizes with green needle shields arranged upright and lying down.
    RTU syringe filling
    Assorted ready to use cartridges in different sizes with green caps and plungers for injectable products.
    RTU cartridge filling
    Featured_Download_Teaser_RTU

    Plan your RTU filling upgrade with confidence

    See all Syntegon RTU filling options by output and container.

    • Match batch size to output
    • Compare RTU machines for each container
    • Check Annex 1 ready and IPC features
    Download

    RTU filling features that eliminate Grade A interventions

    View through a round isolator window onto several white trays loaded with ready to use containers inside an aseptic filling cell.

    600 cpm RTU line with gloveless isolator

    Eliminate manual Grade A interventions while running up to 600 containers per minute with 100% IPC.
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    120-500 containers/h for high value micro batches

    Move aseptic micro batches off large lines and shrink product loss with Versynta microBatch.
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    300 extra hours and 80% fewer plate interventions

    Automate viable monitoring and cut daily Grade A entries for settle plate changes.
    Assorted glass vials in various sizes with grey stoppers and green flip‑off caps for parenteral drugs.
    Case Study

    Stevanato Group boosts RTU vial safety with VHP decontamination

    Syntegon and Stevanato Group tested VHP to decontaminate RTU vials, cutting contamination risk and residual H2O2 while improving flexibility. 

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    Innovative Technologies We enable market leadership.
    Read the full story
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    Innovation Spotlight

    SynTiso gloveless RTU line for high speed filling

    See how the SynTiso platform combines a gloveless isolator and up to 600 containers per minute for large RTU campaigns.

    Explore SynTiso

    Your strategic lifecycle partner for RTU filling

    service-life-cycle
    Lifecycle and Annex 1 consulting for RTU lines

    Plan RTU projects with experts who know Annex 1 from URS to qualification. Service agreements, training and digital support keep performance stable across the lifecycle.

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    service-life-uptime
    Secure availability – every day

    Fast spare parts, qualified support, and preventive maintenance help you avoid unplanned downtime, protect performance, and keep daily operations reliable.

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    service-future-ready
    Make your line fit for tomorrow

    Scalable retrofits and data solutions help you adapt to new demands, improve OEE, and keep your lines future-proof across changing requirements.

    Learn more

    Ready to use filling knowledge hub

    Explore all RTU filling machines
    Explore all RTU filling machines

    Get an in-depth overview of advanced RTU filling solutions designed for syringes, vials, and cartridges.

    Download
    Small and micro batch whitepaper
    Small and micro batch whitepaper

    Learn how small and micro batches are changing pharmaceutical processes.

    Download
    Explore SynTiso – the next evolution.
    Explore SynTiso – the next evolution.

    Learn more about SynTiso, the gloveless solution, that combines regulatory compliance with cutting-edge technology.

    Download

    Frequently asked questions

    Ready to use (RTU) filling uses pre-sterilized vials, syringes and cartridges delivered in tubs or trays. Cleaning, siliconization and sterilization steps move to the packaging supplier, simplifying processing, shortening setup and reducing total cost of ownership.

    RTU filling is especially attractive for high value injectables and clinical supply where flexibility and low product loss matter most.

    Syntegon RTU fill/finish solutions combine isolator or RABS with automation to separate operators from the aseptic area. Gloveless isolators, integrated air management and robotic handling help reduce manual interventions and support Annex 1-focused contamination control.

    Equipment is designed to help you meet applicable regulations and comes with documentation that supports qualification and inspections.

    Syntegon offers RTU filling equipment for small, medium and high outputs and for syringes, vials and cartridges. 

    Versynta microBatch covers micro batches, Versynta FFP covers small commercial outputs, FXS, MLD Advanced and SynTiso platforms cover medium to ultra high speeds.

    A portfolio overview helps you match RTU filling equipment to batch size, container type and Annex 1-focused setups. 

    Download portfolio overview

    Versynta microBatch is a fully automated, gloveless work cell for aseptic micro batches. It fills from 120 to 500 RTU syringes, vials or cartridges per hour with 100% in-process control and 5 inline inspection systems.
    Fast changeovers, minimal product loss and integrated air management make it suitable for clinical trials, cell and gene therapies and start-ups.

    Find out more

    Syntegon uses robotic handling, gloveless isolators and automated IPC to reduce Grade A interventions. 

    Versynta microBatch automates setup and container handling in a closed cell. The robotic Settle Plate Changer replaces viable monitoring plates automatically, which can reduce Grade A interventions by 80 percent and add up to 300 operating hours per year. SynTiso extends this logic to high-speed commercial lines with gloveless automation.

    Yes. Syntegon offers Annex 1 ready equipment and a portfolio of RABS upgrade services for existing lines. Options include barrier retrofits, viable monitoring upgrades such as the robotic Settle Plate Changer, new stopper infeeds and glove integrity testing devices.

    These solutions are designed to help you strengthen contamination control without replacing entire filling lines, while still following your site change control and qualification procedures.

    Many Syntegon RTU filling machines offer 100% in-process control and inline inspection to check each container. 

    • Versynta microBatch combines 100% IPC with 5 integrated inline inspection systems.

    • High speed RTU platforms add integrated checkweighing and reject stations to support process control and container integrity.

    These options help you detect deviations early, protect high value batches and document process performance for QA and regulators.

    The RTU portfolio covers syringes, vials and cartridges and includes combination platforms that can run several formats on one line.

    Modular concepts and changeover by part size help you switch formats faster and support future products without major redesign.

    This flexibility supports RTU fill/finish roadmaps where portfolio, volumes and Annex 1 expectations may change over time.

    Syntegon combines a strong installed base of more than 180 RTU filling lines with a global service network.

    Service specialists support you from project planning and installation to modernization, digital optimization and sustainability analyses.
    Structured service agreements, spare parts and training help you keep RTU lines available and aligned with evolving Annex 1 expectations over the full lifecycle. 

    Interested in filling RTU cartridges, syringes & vials?

    Interested in filling RTU cartridges, syringes & vials?

    Talk to a Syntegon expert to learn more about RTU filling solutions.

    Learn more

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