Some naturally sourced products are liquids or require a fat-based carrier to get absorbed more efficiently during digestion (bioavailability). Such products can easily be dosed as a liquid formulation in a hard capsule with less additives or excipients, which would have been used in a solid formulation. For some active ingredients hard capsules with liquid filling even provide the possibility to form a final oral solid dosage product.
To prevent oil-based liquid capsules from leakage, the capsule must be sealed with a capsule banding, also made from e.g. gelatin or HPMC (Hydroxypropyl methylcellulose, a polymer obtained from plants). If a hot-melt formulation is used, the sealing can be dispensed after a certain specified cooling time, allowing the liquid formulation to return to a solid state.
Banding also provides an additional measure for anti-counterfeiting. By their design hard capsules are intrinsically difficult to copy but the sealing provides an enhanced safety measure to meet regulation requirements.
Syntegon offers a highly accurate and gentle liquid filling technology to fill your liquid into a solid dosing system – the capsule.