Syntegon capsule fillers for liquid filling in capsules with banding

Liquids

Some naturally sourced products are liquids or require a fat-based carrier to get absorbed more efficiently during digestion (bioavailability). Such products can easily be dosed as a liquid formulation in a hard capsule with less additives or excipients, which would have been used in a solid formulation. For some active ingredients hard capsules with liquid filling even provide the possibility to form a final oral solid dosage product.

To prevent oil-based liquid capsules from leakage, the capsule must be sealed with a capsule banding, also made from e.g. gelatin or HPMC (Hydroxypropyl methylcellulose, a polymer obtained from plants). If a hot-melt formulation is used, the sealing can be dispensed after a certain specified cooling time, allowing the liquid formulation to return to a solid state.

Banding also provides an additional measure for anti-counterfeiting. By their design hard capsules are intrinsically difficult to copy but the sealing provides an enhanced safety measure to meet regulation requirements.

Syntegon offers a highly accurate and gentle liquid filling technology to fill your liquid into a solid dosing system – the capsule.

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Dr. Thomas Brinz, Head of Department Pharma Services & OSD Customer Center, Waiblingen

Dr. Thomas Brinz

Head of Department
Pharma Services & OSD Customer Center, Waiblingen
Phone: +49 7151 14-2160

E-mail

Dr. Marcus Knöll

Head of Department
Pharma Services & OSD Customer Center, Schopfheim
Phone: +49 7622 6884-121

E-mail 

Dr. Marcus Knoell, Head of Department Pharma Services & Customer Center, Schopfheim