Freeze Dryer

Freeze-drying systems are suitable for the stabilization of thermolabile and sensitive active substances, such as oncological medicines, vaccines or antibodies.

The modular concept, for vertical as well as for horizontal design, offers the advantage of being suitable for the entire range of GMP-compliant machines, starting with the production of small quantities e.g. for clinical studies up to large production batches. The scalability from small to large production systems as well as the easy adaption to the respective layout situation represent further benefits of the comprehensive modularization.

In addition to the energy-efficient lyophilization process, which is characterized by high process reliability, the freeze dryer also includes all secondary processes such as CIP, SIP and WIT with short cycle times and thus ensures reliable product quality in large quantities.

Defined interfaces to upstream and downstream line components from Syntegon enable efficient processes and a clear responsibility from a single source.

Benefits:

Energy demand & process time

  • Reduction of CIP / SIP times by tilting of shelves as well as minimizing drying times and water consumption
  • Laser welded shelves with less weight and thereby reduced energy consumption
  • Optimized temperature distribution on the shelves for a stable process

Safety

  • Optimized locking system for the doors ensures an extremely low leak rate and contributes to high process reliability
  • Continuously variable height adjustment of the slot door opening to the height of the primary packaging to reduce the air exchange between the barrier system and the FD chamber
  • Improved pressure vessel for an extended lifetime
  • Comprehensively tested and modular software reduces errors and shortens validation times
  • High quality standard components ensure global and quick availability
  • Redundancies for undisturbed operation

Flexibility

  • Flexible loading due to single or double inter-distance of the shelves, selectable in the software
  • Freely adjustable stoppering pressure of the shelves
  • Flexible recipe editor and simple troubleshooting through extensive monitoring in the software
  • Optimal use of available space and short delivery time due to modular design

Usability

  • Fully automated and compact filter integrity testing (WIT)
  • Inline sieve in chamber drain to eliminate glass pieces or stoppers without entering chamber or condenser
  • Optimized access to the ice condenser in vertical systems

Complete filling line from a single source

  • Innovative and fully integrated loading system
  • Optimized interfaces as well as unified documentation and components
  • Quick and smooth project progress
  • Technical Data
    Layout overview
    Shelf dimension
    (width x depth)
    620 x 920 mm 920 x 1.220 mm
    No. of loaded shelves 4 5 6 4 5 6 7 8 9 10 11
    Plant size 2,3 sqm 2,9 sqm 3,4 sqm 4,5 sqm 5,6 sqm 6,7 sqm 7,9 sqm 9,0 sqm 10,1 sqm 11,2 sqm 12,4 sqm
    Ice capacity 60 kg 90 kg Vertical: 140 kg
    Horizontal: 180 kg
    250 kg
    Max. possible shelf interdistance
    (standard = 110 mm)
    176 136 110 143 110 154 129 110 139 123 110
    Vial capacity 2R/4R 8.296 10.370 12.444 17.220 21.525 25.830 30.135 34.440 38.745 43.050 47.355
    6R/8R 4.312 5.390 6.468 9.120 11.400 13.680 15.960 18.240 20.520 22.800 25.080
    10R/15R 3.600 4.500 5.400 7.700 9.625 11.550 13.475 15.400 17.325 19.250 21.175
    20R/25R/30R 2.304 2.880 3.456 4.840 6.050 7.260 8.470 9.680 10.890 12.100 13.310
    Design Vertical design  
      Horizontal design

     

     

    Layout overview
    Shelf dimension
    (width x depth)
    1.520 x 1.520 mm
    No. of loaded shelves 6 7 8 9 10 11 12
    Plant size 13,9 sqm 16,2 sqm 18,5 sqm 20,8 sqm 23,1 sqm 25,4 sqm 27,7 sqm
    Ice capacity 370 kg 560 kg
    Max. possible shelf interdistance
    (standard = 110 mm)
    154 129 110 154 136 122 110
    Vial capacity 2R/4R 55.848 65.156 74.464 83.772 93.080 102.388 111.696
    6R/8R 29.250 34.125 39.000 43.875 48.750 53.625 58.500
    10R/15R 24.636 28.742 32.848 36.954 41.060 45.166 49.272
    20R/25R/30R 15.678 18.291 20.904 23.517 26.130 28.743 31.356
    Design Horizontal design

    Technical data are subject to change

    Options:

    • Flexible fully automated loading system

      • Good and easy to clean
      • Innovative design
    • Laser welded shelves

      • Reproducible quality
      • Reduced weight
    • Automatic double interdistance and tilting of shelves

      • Shortening and optimizing of secondary processes
      • Energy saving
    • Dry primary vacuum pumps

      • Recommended for toxic applications
    • Cooling jacket

      • Reduction of secondary process times
    • Venting system valve block

      • Reduced space requirements
    • Heated gaskets

      • Reduction of condensate
    • Helium leak detector
    • Nitrogen as venting media
    • Technical execution for toxic products
    • Additional sensors

     

    Further equipment is available on request.

  • Request for Quote

    For more information feel free to contact us via our

    RFQ-Form

  • Application Examples

    The flexible recipe editor enables the individual customization of the sublimation process.

    • Vials (bulk or nested)
    • Bulk (open or closed)
    • Toxic/high potent products (BSL 1 – BSL 6)
    • Further applications on request
  • Parts and Service

    Syntegon Technology Services – your reliable partner
    By acquiring a packaging machine from Syntegon, you gain access to an extensive range of after-sales services. Syntegon Technology Services is your full-range solution provider with a strong global network, acting on a local basis. Whenever you require practical assistance or consulting, Syntegon experts can support you on-site. Our comprehensive portfolio ranges from standard services to complete service packages, tailored to your specific needs.

    Go to Syntegon Technology Services

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