We support you throughout the entire machine life cycle, from spare parts management to digital line optimization. Service agreements are a key element of our portfolio structure. Together, we tailor our solutions to your individual needs. Our global network of experts supports you with maintenance planning, technical support, and modernizations, as well as operator training and end of life services. With our digital solutions, you gain control over your production processes and create transparency on product and machine data anytime, anywhere.
High-shear mixer granulator
Process robustness and high efficiency are the main requirements for high-quality granulation in a high-shear mixer. Our technology is based on the unique Gentlewing impeller. The high-shear mixer granulator provides perfect mixing in short time and allows for a wide process window in terms of e.g. tip speed, filling level and mixing duration. At the same time, wall caking and product residues are minimized. The equipment’s intelligent features facilitate safe product transfer via a wet mill into the fluid bed, avoiding operator intervention. For older, already registered formulations, a traditional 3-blade impeller is available.
High-shear mixer technology & features
Gentlewing: Convincing mixing and granulation results
The Hüttlin Gentlewing is designed to achieve superior mixing and granulation results. The impeller’s shape matches the contour of the mixing container, while its angled blades ensure forced high-shear mixing of the product.
The prolonged blades further avoid wall caking, resulting in a higher yield.
Gentlewing or 3-blade impeller: you have the choice!
You have the option to choose between the innovative Gentlewing impeller and a traditional 3-blade impeller for older formulations, which are already registered with this technology.
Top or bottom drive: we offer total flexibility
Our technology is available in a top (HTG) or bottom drive (HBG) execution.
Both share the same geometry, resulting in no process difference between top and bottom drive, achieving consistent high-quality results. The Gentlewing’s design and the vertical chopper support a high batch variability of 20 – 80 %.
Automatic end point detection
Besides time and current measurement, we can additionally offer torque measurement to determine the end point of granulation as a validatable end point value.
Choose your preferred charging option
Depending on your products’ characteristics and your plant’s layout, you can choose between different charging options: pneumatically by continuous or intermittent vacuum or alternatively by gravity filling. Especially for critical products, intermittent vacuum drastically reduces the filter load during charging.
Closed process for the highest safety
In both our top and bottom drive executions, the Gentlewing and chopper shafts are equipped with a purged sealing system. The product container’s lid features an inflatable seal as well as an interlocking device to avoid cross-contamination. It further ensures product and operator safety.
Efficient pharma wall installation
The wall installation enables a true separation of the GMP and technical area, reducing the required space in the pharma room. All drives and supply lines are accessible via the technical area for time-efficient and safe maintenance.
All benefits in a single pot
The Hüttlin single pot combines all benefits of the leak-tight top-drive concept with a smart, efficient energy transfer via heated bowl, lid, filter housing and shaft, as well as an optimized vacuum system with optional solvent recovery. This concept meets the highest requirements regarding process times, product quality and handling.
Cleaning – automated and efficient
Efficiency is one of the main benefits of our cleaning systems. Depending on your requirements, you can flexibly choose either our basic automated cleaning system or the advanced automated UltraClean technology. Thanks to its in-place cleaning, the UltraClean stainless-steel filter significantly reduces cleaning times and ensures reproducible results.
Are you looking for a small R&D tabletop mixer?
Mycromix granulates small amounts of products. Due to interchangeable bowls of 0.5, 1.0, 2.5, 5.0 and 10 liters, you can process a wide range of batch sizes. Mycromix features the same unique Gentlewing impeller and vertical chopper as our production-scale high-shear mixers. Mycromix is available with various options, such as preparation for organic solvents, heating/cooling jackets or a 3-blade impeller. In case you are seeking to expand your R&D capabilities, our Solidlab 1 and Solidlab 2 Plus fluid beds for drying perfectly complement the Mycromix table-top solution.
Unlike most other solutions in the market, the Solidlab 1 comes with our PROVICON control system featuring open recipe creation and management for a time-saving product development.
Use case scenarios
Outstanding granule quality
Whether you compress granules into tablets or fill them into capsules or sachets, e.g. for nutraceuticals – our high-shear mixer means outstanding quality for any dosage form.
Tablets at their best
Outstanding granule properties like smooth flowability and an ideal particle size distribution result in excellent compression characteristics– even at very low API concentration, e.g. for cancer therapy.
Effervescent tablets support easy oral administration, but prove challenging in terms of production. Our sophisticated single pot system is perfectly suited to produce granules for highly stable effervescent tablets.
Yes we capsule
Granules, pellets, and mini tablets are perfectly suited for fixed-dose or personalized combination capsules, e.g. anti-infective drugs. Our fluid bed granulators ensure optimum quality of the individual components.
Technical data of our high shear mixer
|Product container volume (l)||0.5 – 10||25 – 150||300 – 1,800||150 – 1,200||150 – 1,200|
|Batch range (kg)||0.1 – 3.5||2.5 – 60||30 – 720||15 – 480||15 – 480|
|At a density of (kg/l)||0.5||0.5||0.5||0.5||0.5|
Why choose a Syntegon high-shear mixer?
Oral solid dosage forms (OSD) are our specialty: in the course of our long business history, we have been supporting countless industry players across the globe and sharing our rich expertise in high-shear mixing. As an innovation-driven company, we are far from maintaining the status quo: over the last few years, we have been actively pursuing new ways to advance OSD manufacturing. Download our selection of brochures to find out more.
OSD: Many facets – one partner
Oral solid dose (OSD) manufacturing is a demanding endeavor. There is no better partner to tackle those tasks with than Syntegon. Our OSD services and process technology will make your production a rock-solid success. Find out more in this video.